Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Kdm4b (lysine (K)-specific demethylase 4B) Mus musculus
Symbol: Kdm4b
Name: lysine (K)-specific demethylase 4B
Description: Exhibits histone demethylase activity (H3-K9 specific). Involved in histone H3-K36 demethylation; histone H3-K9 demethylation; and negative regulation of histone H3-K9 trimethylation. Localizes to nuclear pericentric heterochromatin. Is expressed in several structures, including early conceptus; genitourinary system; heart; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in breast cancer; colorectal cancer; malignant peripheral nerve sheath tumor; and stomach cancer. Orthologous to human KDM4B (lysine demethylase 4B); PARTICIPATES IN histone modification pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4732474L06Rik; [histone H3]-trimethyl-L-lysine(9) demethylase 4B; jmjC domain-containing histone demethylation protein 3B; Jmjd2b; jumonji domain containing 2B; jumonji domain-containing protein 2B; lysine-specific demethylase 4B; MGC6349; mKIAA0876
Homo sapiens (human) : KDM4B (lysine demethylase 4B)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Kdm4b (lysine demethylase 4B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kdm4b (lysine demethylase 4B)
Pan paniscus (bonobo/pygmy chimpanzee) : KDM4B (lysine demethylase 4B)
Canis lupus familiaris (dog) : KDM4B (lysine demethylase 4B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kdm4b (lysine demethylase 4B)
Sus scrofa (pig) : KDM4B (lysine demethylase 4B)
Chlorocebus sabaeus (African green monkey) : KDM4B (lysine demethylase 4B)
Heterocephalus glaber (naked mole-rat) : Kdm4b (lysine demethylase 4B)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1756,326,062 - 56,402,870 (+)EnsemblGRCm38mm10GRCm38
GRCm381756,325,970 - 56,403,774 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371756,465,473 - 56,542,296 (+)NCBIGRCm37mm9NCBIm37
MGSCv361755,959,801 - 56,036,572 (+)NCBImm8
Celera1760,697,409 - 60,748,612 (+)NCBICelera
Cytogenetic Map17DNCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Kdm4b
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1558448
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.