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Gene: Kdm4b (lysine (K)-specific demethylase 4B) Mus musculus
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Symbol: Kdm4b
Name: lysine (K)-specific demethylase 4B
Description: Exhibits histone demethylase activity (H3-K9 specific). Involved in histone H3-K36 demethylation; histone H3-K9 demethylation; and negative regulation of histone H3-K9 trimethylation. Localizes to nuclear pericentric heterochromatin. Is expressed in several structures, including early conceptus; genitourinary system; heart; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in breast cancer; colorectal cancer; malignant peripheral nerve sheath tumor; and stomach cancer. Orthologous to human KDM4B (lysine demethylase 4B); PARTICIPATES IN histone modification pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4732474L06Rik; [histone H3]-trimethyl-L-lysine(9) demethylase 4B; jmjC domain-containing histone demethylation protein 3B; Jmjd2b; jumonji domain containing 2B; jumonji domain-containing protein 2B; lysine-specific demethylase 4B; MGC6349; mKIAA0876
Orthologs:
Homo sapiens (human) : KDM4B (lysine demethylase 4B)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Kdm4b (lysine demethylase 4B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kdm4b (lysine demethylase 4B)
Pan paniscus (bonobo/pygmy chimpanzee) : KDM4B (lysine demethylase 4B)
Canis lupus familiaris (dog) : KDM4B (lysine demethylase 4B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kdm4b (lysine demethylase 4B)
Sus scrofa (pig) : KDM4B (lysine demethylase 4B)
Chlorocebus sabaeus (African green monkey) : KDM4B (lysine demethylase 4B)
Heterocephalus glaber (naked mole-rat) : Kdm4b (lysine demethylase 4B)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1756,326,062 - 56,402,870 (+)EnsemblGRCm38mm10GRCm38
GRCm381756,325,970 - 56,403,774 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371756,465,473 - 56,542,296 (+)NCBIGRCm37mm9NCBIm37
MGSCv361755,959,801 - 56,036,572 (+)NCBImm8
Celera1760,697,409 - 60,748,612 (+)NCBICelera
Cytogenetic Map17DNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Kdm4b
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1558448
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.