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Gene: Kdm6a (lysine (K)-specific demethylase 6A) Mus musculus
Symbol: Kdm6a
Name: lysine (K)-specific demethylase 6A
CRRD ID: 1558450
Description: Exhibits DNA binding activity; histone demethylase activity (H3-K27 specific); and identical protein binding activity. Involved in several processes, including chordate embryonic development; chromatin organization; and embryonic morphogenesis. Localizes to histone methyltransferase complex. Is expressed in several structures, including early conceptus; gonad; liver; lung; and spleen. Used to study chronic myelomonocytic leukemia. Human ortholog(s) of this gene implicated in Kabuki syndrome; acute lymphoblastic leukemia; and esophagus squamous cell carcinoma. Orthologous to human KDM6A (lysine demethylase 6A); PARTICIPATES IN histone modification pathway; renal cell carcinoma pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4lysine (K)-specific demethylase 6A; [histone H3]-trimethyl-L-lysine(27) demethylase 6A; histone demethylase UTX; lysine-specific demethylase 6A; ubiquitously transcribed tetratricopeptide repeat gene, X chromosome; ubiquitously transcribed TPR protein on the X chromosome; ubiquitously transcribed X chromosome tetratricopeptide repeat protein; Utx
Homo sapiens (human) : KDM6A (lysine demethylase 6A)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Kdm6a (lysine demethylase 6A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kdm6a (lysine demethylase 6A)
Pan paniscus (bonobo/pygmy chimpanzee) : KDM6A (lysine demethylase 6A)
Canis lupus familiaris (dog) : KDM6A (lysine demethylase 6A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kdm6a (lysine demethylase 6A)
Sus scrofa (pig) : KDM6A (lysine demethylase 6A)
Chlorocebus sabaeus (African green monkey) : KDM6A (lysine demethylase 6A)
Heterocephalus glaber (naked mole-rat) : Kdm6a (lysine demethylase 6A)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39X18,027,101 - 18,146,175 (+)NCBI
GRCm38X18,160,862 - 18,279,936 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX18,162,575 - 18,279,936 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X17,739,793 - 17,856,484 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X17,319,626 - 17,436,317 (+)NCBImm8
CeleraX15,748,215 - 15,864,723 (+)NCBICelera
Cytogenetic MapXA1.2-A1.3NCBI
cM MapX13.45NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Kdm6a
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1558450
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.