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Gene: Shb (src homology 2 domain-containing transforming protein B) Mus musculus
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Symbol: Shb
Name: src homology 2 domain-containing transforming protein B
Description: Predicted to have phosphotyrosine residue binding activity. Involved in several processes, including hematopoietic stem cell proliferation; negative regulation of oocyte maturation; and positive regulation of immune response. Predicted to localize to cytoplasmic ribonucleoprotein granule; cytosol; and nucleoplasm. Is expressed in brain; molar; and sensory organ. Orthologous to human SHB (SH2 domain containing adaptor protein B); PARTICIPATES IN platelet-derived growth factor signaling pathway; vascular endothelial growth factor signaling pathway; INTERACTS WITH 1,2-dichloroethane; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: BC028832; SH2 domain-containing adapter protein B
Orthologs:
Homo sapiens (human) : SHB (SH2 domain containing adaptor protein B)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Shb (SH2 domain containing adaptor protein B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Shb (SH2 domain containing adaptor protein B)
Pan paniscus (bonobo/pygmy chimpanzee) : SHB (SH2 domain containing adaptor protein B)
Canis lupus familiaris (dog) : SHB (SH2 domain containing adaptor protein B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Shb (SH2 domain containing adaptor protein B)
Sus scrofa (pig) : SHB (SH2 domain containing adaptor protein B)
Chlorocebus sabaeus (African green monkey) : SHB (SH2 domain containing adaptor protein B)
Heterocephalus glaber (naked mole-rat) : Shb (SH2 domain containing adaptor protein B)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl445,423,278 - 45,532,470 (-)EnsemblGRCm38mm10GRCm38
GRCm38445,423,276 - 45,530,828 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37445,436,148 - 45,543,700 (-)NCBIGRCm37mm9NCBIm37
MGSCv36444,263,381 - 44,370,910 (-)NCBImm8
MGSCv36445,444,376 - 45,551,862 (-)NCBImm8
Celera445,444,918 - 45,556,568 (-)NCBICelera
Cytogenetic Map4B1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Shb
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1558467
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.