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Gene: Tlr7 (toll-like receptor 7) Mus musculus
Symbol: Tlr7
Name: toll-like receptor 7
CRRD ID: 1558497
Description: Exhibits siRNA binding activity and single-stranded RNA binding activity. Involved in several processes, including defense response to virus; positive regulation of cytokine production; and toll-like receptor 7 signaling pathway. Localizes to cytoplasmic vesicle; endoplasmic reticulum; and lysosome. Is expressed in brain and liver. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human TLR7 (toll like receptor 7); PARTICIPATES IN Toll-like receptor signaling pathway; influenza A pathway; measles pathway; INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Toll like receptor 7
Homo sapiens (human) : TLR7 (toll like receptor 7)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tlr7 (toll-like receptor 7)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tlr7 (toll like receptor 7)
Pan paniscus (bonobo/pygmy chimpanzee) : TLR7 (toll like receptor 7)
Canis lupus familiaris (dog) : TLR7 (toll like receptor 7)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tlr7 (toll like receptor 7)
Chlorocebus sabaeus (African green monkey) : TLR7 (toll like receptor 7)
Heterocephalus glaber (naked mole-rat) : Tlr7 (toll like receptor 7)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39X166,086,376 - 166,113,570 (-)NCBI
GRCm38X167,303,380 - 167,330,574 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX167,304,929 - 167,330,558 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X163,742,863 - 163,768,460 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X162,649,036 - 162,674,633 (-)NCBImm8
CeleraX150,452,330 - 150,504,044 (-)NCBICelera
Cytogenetic MapXF5NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Tlr7
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1558497
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2020-11-17
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.