Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Spen (spen family transcription repressor) Mus musculus
Symbol: Spen
Name: spen family transcription repressor
Description: Exhibits DNA-binding transcription factor activity; single-stranded DNA binding activity; and transcription corepressor activity. Involved in negative regulation of transcription, DNA-templated and positive regulation of transcription, DNA-templated. Localizes to the nucleus. Is expressed in central nervous system; genitourinary system; hemolymphoid system; sensory organ; and tooth. Orthologous to human SPEN (spen family transcriptional repressor); PARTICIPATES IN Notch signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; choline.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Mint; mKIAA0929; Msx2 interacting nuclear target protein; msx2-interacting protein; SMART/HDAC1-associated repressor protein; SPEN homolog, transcriptional regulator; SPEN homolog, transcriptional regulator (Drosophila)
Homo sapiens (human) : SPEN (spen family transcriptional repressor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Spen (spen family transcriptional repressor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Spen (spen family transcriptional repressor)
Pan paniscus (bonobo/pygmy chimpanzee) : SPEN (spen family transcriptional repressor)
Canis lupus familiaris (dog) : SPEN (spen family transcriptional repressor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Spen (spen family transcriptional repressor)
Sus scrofa (pig) : SPEN (spen family transcriptional repressor)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm384141,467,885 - 141,538,644 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv374141,023,805 - 141,094,512 (-)NCBIGRCm37mm9NCBIm37
MGSCv364140,740,934 - 140,794,407 (-)NCBImm8
Celera4143,285,155 - 143,361,424 (-)NCBICelera
Cytogenetic Map4 D3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Spen
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1558566
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.