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Gene: Ern1 (endoplasmic reticulum (ER) to nucleus signalling 1) Mus musculus
Symbol: Ern1
Name: endoplasmic reticulum (ER) to nucleus signalling 1
Description: Exhibits endoribonuclease activity; protein homodimerization activity; and protein serine/threonine kinase activity. Involved in several processes, including IRE1-mediated unfolded protein response; positive regulation of RNA splicing; and protein phosphorylation. Localizes to several cellular components, including the AIP1-IRE1 complex; endoplasmic reticulum membrane; and nuclear inner membrane. Is expressed in several structures, including adrenal medulla; brain; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human ERN1 (endoplasmic reticulum to nucleus signaling 1); PARTICIPATES IN endoplasmic reticulum stress - the unfolded protein response pathway; Alzheimer's disease pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (S)-nicotine; 1,2-dichloroethane; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Type: protein-coding
Also known as: 9030414B18Rik; AI225830; C85377; endoplasmic reticulum-to-nucleus signaling 1; inositol-requiring 1 alpha; inositol-requiring protein 1; ire1-alpha; Ire1a; Ire1alpha; Ire1p; serine/threonine-protein kinase/endoribonuclease IRE1
Homo sapiens (human) : ERN1 (endoplasmic reticulum to nucleus signaling 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ern1 (endoplasmic reticulum to nucleus signaling 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ern1 (endoplasmic reticulum to nucleus signaling 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ERN1 (endoplasmic reticulum to nucleus signaling 1)
Canis lupus familiaris (dog) : ERN1 (endoplasmic reticulum to nucleus signaling 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ern1 (endoplasmic reticulum to nucleus signaling 1)
Sus scrofa (pig) : ERN1 (endoplasmic reticulum to nucleus signaling 1)
Chlorocebus sabaeus (African green monkey) : ERN1 (endoplasmic reticulum to nucleus signaling 1)
Heterocephalus glaber (naked mole-rat) : Ern1 (endoplasmic reticulum to nucleus signaling 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl11106,394,650 - 106,487,852 (-)Ensembl
GRCm3811106,397,620 - 106,487,796 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3711106,258,934 - 106,349,110 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611106,213,710 - 106,303,886 (-)NCBImm8
Celera11118,128,975 - 118,219,164 (-)NCBICelera
Cytogenetic Map11 E1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Ern1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1558600
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2019-12-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.