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Gene: Setdb1 (SET domain, bifurcated 1) Mus musculus
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Symbol: Setdb1
Name: SET domain, bifurcated 1
CRRD ID: 1558610
Description: Exhibits DNA binding activity; histone methyltransferase activity (H3-K9 specific); and promoter-specific chromatin binding activity. Involved in several processes, including histone H3-K9 trimethylation; inner cell mass cell proliferation; and regulation of transcription, DNA-templated. Localizes to nucleus. Colocalizes with nuclear chromatin. Is expressed in several structures, including 1-cell stage embryo; central nervous system; long bone; oocyte; and white fat. Human ortholog(s) of this gene implicated in autistic disorder and lung cancer. Orthologous to human SETDB1 (SET domain bifurcated histone lysine methyltransferase 1); PARTICIPATES IN histone modification pathway; homocysteine metabolic pathway; methionine cycle/metabolic pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AU022152; ERG-associated protein with SET domain; ESE; ESET; histone-lysine N-methyltransferase SETDB1; KMT1E; MGC90670; mKIAA0067; SET domain bifurcated 1; SET domain ERG-associated histone methyltransferase
Orthologs:
Related Pseudogenes: Gm4349  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39395,230,836 - 95,264,513 (-)NCBI
GRCm38395,323,525 - 95,357,202 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl395,323,525 - 95,357,202 (-)EnsemblGRCm38mm10GRCm38
MGSCv37395,127,447 - 95,161,124 (-)NCBIGRCm37mm9NCBIm37
MGSCv36395,408,929 - 95,442,577 (-)NCBImm8
Celera396,754,826 - 96,788,575 (-)NCBICelera
Cytogenetic Map3F2.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Setdb1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1558610
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2020-10-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.