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Gene: Setdb1 (SET domain, bifurcated 1) Mus musculus
Symbol: Setdb1
Name: SET domain, bifurcated 1
CRRD ID: 1558610
Description: Exhibits DNA binding activity; histone methyltransferase activity (H3-K9 specific); and promoter-specific chromatin binding activity. Involved in several processes, including histone H3-K9 trimethylation; inner cell mass cell proliferation; and regulation of transcription, DNA-templated. Localizes to nucleus. Colocalizes with nuclear chromatin. Is expressed in several structures, including 1-cell stage embryo; central nervous system; long bone; oocyte; and white fat. Human ortholog(s) of this gene implicated in autistic disorder and lung cancer. Orthologous to human SETDB1 (SET domain bifurcated histone lysine methyltransferase 1); PARTICIPATES IN histone modification pathway; homocysteine metabolic pathway; methionine cycle/metabolic pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AU022152; ERG-associated protein with SET domain; ESE; ESET; histone-lysine N-methyltransferase SETDB1; KMT1E; MGC90670; mKIAA0067; SET domain bifurcated 1; SET domain ERG-associated histone methyltransferase
Related Pseudogenes: Gm4349  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39395,230,836 - 95,264,513 (-)NCBI
GRCm38395,323,525 - 95,357,202 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl395,323,525 - 95,357,202 (-)EnsemblGRCm38mm10GRCm38
MGSCv37395,127,447 - 95,161,124 (-)NCBIGRCm37mm9NCBIm37
MGSCv36395,408,929 - 95,442,577 (-)NCBImm8
Celera396,754,826 - 96,788,575 (-)NCBICelera
Cytogenetic Map3F2.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Setdb1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1558610
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2020-10-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.