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Gene: Sufu (SUFU negative regulator of hedgehog signaling) Rattus norvegicus
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Symbol: Sufu
Name: SUFU negative regulator of hedgehog signaling
Description: Predicted to have beta-catenin binding activity; protein kinase binding activity; and transcription factor binding activity. Predicted to be involved in several processes, including animal organ development; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning; and regulation of transcription, DNA-templated. Predicted to localize to cilium; cytoplasm; and nucleoplasm. Human ortholog(s) of this gene implicated in Joubert syndrome 32; familial meningioma; medulloblastoma; and nevoid basal cell carcinoma syndrome. Orthologous to human SUFU (SUFU negative regulator of hedgehog signaling); PARTICIPATES IN Hedgehog signaling pathway; basal cell carcinoma pathway; INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: suppressor of fused; suppressor of fused homolog; suppressor of fused homolog (Drosophila)
Orthologs:
Homo sapiens (human) : SUFU (SUFU negative regulator of hedgehog signaling)  HGNC  Alliance
Mus musculus (house mouse) : Sufu (SUFU negative regulator of hedgehog signaling)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sufu (SUFU negative regulator of hedgehog signaling)
Pan paniscus (bonobo/pygmy chimpanzee) : SUFU (SUFU negative regulator of hedgehog signaling)
Canis lupus familiaris (dog) : SUFU (SUFU negative regulator of hedgehog signaling)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sufu (SUFU negative regulator of hedgehog signaling)
Sus scrofa (pig) : SUFU (SUFU negative regulator of hedgehog signaling)
Chlorocebus sabaeus (African green monkey) : SUFU (SUFU negative regulator of hedgehog signaling)
Heterocephalus glaber (naked mole-rat) : Sufu (SUFU negative regulator of hedgehog signaling)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01266,143,766 - 266,241,742 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1266,143,818 - 266,239,016 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01273,574,697 - 273,672,663 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41251,612,377 - 251,708,109 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1241,040,495 - 241,135,358 (+)NCBICelera
Cytogenetic Map1q54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Sufu
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1559462
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.