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Gene: Tpm2 (tropomyosin 2) Rattus norvegicus
Symbol: Tpm2
Name: tropomyosin 2
CRRD ID: 1559479
Description: Exhibits actin filament binding activity; protein heterodimerization activity; and protein homodimerization activity. Predicted to be involved in actin filament organization; muscle contraction; and regulation of ATPase activity. Localizes to actin cytoskeleton. Human ortholog(s) of this gene implicated in distal arthrogryposis type 1A and nemaline myopathy 4. Orthologous to human TPM2 (tropomyosin 2); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: beta-tropomyosin; MGC109519; similar to tropomyosin 1, embryonic fibroblast - rat; tropomyosin; tropomyosin 2, beta; tropomyosin beta chain; tropomyosin-2
Homo sapiens (human) : TPM2 (tropomyosin 2)  HGNC  Alliance
Mus musculus (house mouse) : Tpm2 (tropomyosin 2, beta)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tpm2 (tropomyosin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TPM2 (tropomyosin 2)
Canis lupus familiaris (dog) : TPM2 (tropomyosin 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tpm2 (tropomyosin 2)
Sus scrofa (pig) : TPM2 (tropomyosin 2)
Chlorocebus sabaeus (African green monkey) : TPM2 (tropomyosin 2)
Heterocephalus glaber (naked mole-rat) : Tpm2 (tropomyosin 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0559,016,616 - 59,025,971 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl559,016,622 - 59,025,631 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0563,541,215 - 63,550,146 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4559,994,101 - 60,003,261 (-)NCBIRGSC3.4rn4RGSC3.4
Celera556,351,476 - 56,360,486 (-)NCBICelera
Cytogenetic Map5q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Tpm2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1559479
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2020-10-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.