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Gene: Tpm2 (tropomyosin 2) Rattus norvegicus
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Symbol: Tpm2
Name: tropomyosin 2
CRRD ID: 1559479
Description: Exhibits actin filament binding activity; protein heterodimerization activity; and protein homodimerization activity. Predicted to be involved in actin filament organization; muscle contraction; and regulation of ATPase activity. Localizes to actin cytoskeleton. Human ortholog(s) of this gene implicated in distal arthrogryposis type 1A and nemaline myopathy 4. Orthologous to human TPM2 (tropomyosin 2); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: beta-tropomyosin; MGC109519; similar to tropomyosin 1, embryonic fibroblast - rat; tropomyosin; tropomyosin 2, beta; tropomyosin beta chain; tropomyosin-2
Orthologs:
Homo sapiens (human) : TPM2 (tropomyosin 2)  HGNC  Alliance
Mus musculus (house mouse) : Tpm2 (tropomyosin 2, beta)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tpm2 (tropomyosin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TPM2 (tropomyosin 2)
Canis lupus familiaris (dog) : TPM2 (tropomyosin 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tpm2 (tropomyosin 2)
Sus scrofa (pig) : TPM2 (tropomyosin 2)
Chlorocebus sabaeus (African green monkey) : TPM2 (tropomyosin 2)
Heterocephalus glaber (naked mole-rat) : Tpm2 (tropomyosin 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0559,016,616 - 59,025,971 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl559,016,622 - 59,025,631 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0563,541,215 - 63,550,146 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4559,994,101 - 60,003,261 (-)NCBIRGSC3.4rn4RGSC3.4
Celera556,351,476 - 56,360,486 (-)NCBICelera
Cytogenetic Map5q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Tpm2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1559479
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2020-10-06
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.