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Gene: Tpm2 (tropomyosin 2) Rattus norvegicus
Symbol: Tpm2
Name: tropomyosin 2
Description: Exhibits actin filament binding activity; protein heterodimerization activity; and protein homodimerization activity. Predicted to be involved in actin filament organization and regulation of ATPase activity. Localizes to the actin cytoskeleton. Human ortholog(s) of this gene implicated in nemaline myopathy 4. Orthologous to human TPM2 (tropomyosin 2); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: beta-tropomyosin; MGC109519; similar to tropomyosin 1, embryonic fibroblast - rat; tropomyosin; tropomyosin 2, beta; tropomyosin beta chain; tropomyosin-2
Homo sapiens (human) : TPM2 (tropomyosin 2)  HGNC  Alliance
Mus musculus (house mouse) : Tpm2 (tropomyosin 2, beta)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tpm2 (tropomyosin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TPM2 (tropomyosin 2)
Canis lupus familiaris (dog) : TPM2 (tropomyosin 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tpm2 (tropomyosin 2)
Sus scrofa (pig) : TPM2 (tropomyosin 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0559,016,616 - 59,025,971 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0563,541,215 - 63,550,146 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4559,994,101 - 60,003,261 (-)NCBIRGSC3.4rn4RGSC3.4
Celera556,351,476 - 56,360,486 (-)NCBICelera
Cytogenetic Map5q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Tpm2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1559479
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.