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Gene: Med1 (mediator complex subunit 1) Rattus norvegicus
Symbol: Med1
Name: mediator complex subunit 1
Description: Exhibits DNA binding activity; nuclear hormone receptor binding activity; and transcription coregulator activity. Contributes to ubiquitin protein ligase activity. Involved in several processes, including cellular response to thyroid hormone stimulus; positive regulation of transcription by RNA polymerase II; and protein ubiquitination. Localizes to several cellular components, including chromatin; protein-DNA complex; and ubiquitin ligase complex. Orthologous to human MED1 (mediator complex subunit 1); PARTICIPATES IN cortisol signaling pathway; estrogen signaling pathway; RNA polymerase II transcription pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amphetamine; bisphenol A.
Type: protein-coding
Also known as: LOC497991; mediator of RNA polymerase II transcription subunit 1; RGD1559552; similar to peroxisome proliferator-activated receptor binding protein
Homo sapiens (human) : MED1 (mediator complex subunit 1)  HGNC  Alliance
Mus musculus (house mouse) : Med1 (mediator complex subunit 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Med1 (mediator complex subunit 1)
Pan paniscus (bonobo/pygmy chimpanzee) : MED1 (mediator complex subunit 1)
Canis lupus familiaris (dog) : MED1 (mediator complex subunit 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Med1 (mediator complex subunit 1)
Sus scrofa (pig) : MED1 (mediator complex subunit 1)
Chlorocebus sabaeus (African green monkey) : MED1 (mediator complex subunit 1)
Heterocephalus glaber (naked mole-rat) : Med1 (mediator complex subunit 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01086,101,560 - 86,145,271 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1086,103,600 - 86,144,880 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01085,899,172 - 85,942,182 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41086,917,525 - 86,959,080 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1081,896,663 - 81,937,929 (-)NCBICelera
Cytogenetic Map10q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Med1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1559552
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.