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Gene: Ern1 (endoplasmic reticulum to nucleus signaling 1) Rattus norvegicus
Symbol: Ern1
Name: endoplasmic reticulum to nucleus signaling 1
CRRD ID: 1559716
Description: Exhibits Hsp90 protein binding activity. Involved in cellular response to glucose stimulus; cellular response to hydrogen peroxide; and cellular response to manganese ion. Predicted to localize to several cellular components, including AIP1-IRE1 complex; IRE1-RACK1-PP2A complex; and endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human ERN1 (endoplasmic reticulum to nucleus signaling 1); PARTICIPATES IN endoplasmic reticulum stress - the unfolded protein response pathway; Alzheimer's disease pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (+)-schisandrin B; 1,4-dithiothreitol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Also known as: endoplasmic reticulum (ER) to nucleus signalling 1; LOC498013; RGD1559716; serine/threonine-protein kinase/endoribonuclease IRE1; similar to protein kinase/endoribonuclease(IRE1) alpha
Homo sapiens (human) : ERN1 (endoplasmic reticulum to nucleus signaling 1)  HGNC  Alliance
Mus musculus (house mouse) : Ern1 (endoplasmic reticulum (ER) to nucleus signalling 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ern1 (endoplasmic reticulum to nucleus signaling 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ERN1 (endoplasmic reticulum to nucleus signaling 1)
Canis lupus familiaris (dog) : ERN1 (endoplasmic reticulum to nucleus signaling 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ern1 (endoplasmic reticulum to nucleus signaling 1)
Sus scrofa (pig) : ERN1 (endoplasmic reticulum to nucleus signaling 1)
Chlorocebus sabaeus (African green monkey) : ERN1 (endoplasmic reticulum to nucleus signaling 1)
Heterocephalus glaber (naked mole-rat) : Ern1 (endoplasmic reticulum to nucleus signaling 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01094,588,555 - 94,682,072 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1094,588,555 - 94,681,914 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01094,336,640 - 94,429,967 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41095,794,488 - 95,855,895 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1090,003,932 - 90,064,578 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Ern1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1559716
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2020-09-29
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.