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Gene: Phox2b (paired-like homeobox 2b) Rattus norvegicus
Symbol: Phox2b
Name: paired-like homeobox 2b
Description: Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including nervous system development; positive regulation of cold-induced thermogenesis; and regulation of respiratory gaseous exchange by nervous system process. Localizes to nucleus. Human ortholog(s) of this gene implicated in congenital central hypoventilation syndrome. Orthologous to human PHOX2B (paired like homeobox 2B); INTERACTS WITH bisphenol A; copper atom; copper(0).
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOW QUALITY PROTEIN: paired mesoderm homeobox protein 2B; NBPhox; neuroblastoma Phox; paired mesoderm homeobox protein 2B
Homo sapiens (human) : PHOX2B (paired like homeobox 2B)  HGNC  Alliance
Mus musculus (house mouse) : Phox2b (paired-like homeobox 2b)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Phox2b (paired like homeobox 2B)
Pan paniscus (bonobo/pygmy chimpanzee) : PHOX2B (paired like homeobox 2B)
Canis lupus familiaris (dog) : PHOX2B (paired like homeobox 2B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Phox2b (paired like homeobox 2B)
Sus scrofa (pig) : PHOX2B (paired like homeobox 2B)
Chlorocebus sabaeus (African green monkey) : PHOX2B (paired like homeobox 2B)
Heterocephalus glaber (naked mole-rat) : Phox2b (paired like homeobox 2B)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01442,711,169 - 42,718,707 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1442,714,315 - 42,717,010 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01442,510,540 - 42,514,526 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41443,675,180 - 43,677,970 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1440,218,744 - 40,226,258 (+)NCBICelera
Cytogenetic Map14p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Phox2b
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1560582
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.