Gene: Lrrk2 (leucine-rich repeat kinase 2) Rattus norvegicus
Analyze
Symbol: Lrrk2
Name: leucine-rich repeat kinase 2
Description: Predicted to have several functions, including cytoskeletal protein binding activity, enzyme regulator activity, and protein kinase activity; involved in several processes, including cellular response to organic cyclic compound, nervous system development, and positive regulation of transport; localizes to several cellular components, including the cytoplasm, intracellular membrane-bounded organelle, and neuron projection; used to study neurodegenerative disease; biomarker of diabetic neuropathy; orthologous to human LRRK2 (leucine rich repeat kinase 2); PARTICIPATES IN Parkinson's disease pathway; INTERACTS WITH (RS)-amphetamine; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: leucine-rich repeat serine/threonine-protein kinase 2
Orthologs:
Homo sapiens (human) : LRRK2 (leucine rich repeat kinase 2)  HGNC  Alliance
Mus musculus (house mouse) : Lrrk2 (leucine-rich repeat kinase 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lrrk2 (leucine rich repeat kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : LRRK2 (leucine rich repeat kinase 2)
Canis lupus familiaris (dog) : LRRK2 (leucine rich repeat kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lrrk2 (leucine rich repeat kinase 2)
Sus scrofa (pig) : LRRK2 (leucine rich repeat kinase 2)
more info ...
Allele / Splice: Lrrk1em1SageLrrk2em1Sage   Lrrk2em1Sage  
Genetic Models: LE-Lrrk2em1Sage-/- LE-Lrrk2em1Sage LE-Lrrk1em1Sage-/-Lrrk2em1Sage-/- LE-Lrrk1em1SageLrrk2em1Sage
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.07132,857,311 - 133,018,549 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07132,531,591 - 132,694,226 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47130,105,902 - 130,267,747 (+)NCBIRGSC3.4rn4RGSC3.4
Celera7119,264,946 - 119,423,875 (+)NCBICelera
Cytogenetic Map7q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Lrrk2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1561168
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.