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Gene: Cbl (Cbl proto-oncogene) Rattus norvegicus
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Symbol: Cbl
Name: Cbl proto-oncogene
Description: Exhibits several functions, including SH3 domain binding activity; phosphatidylinositol 3-kinase regulatory subunit binding activity; and ubiquitin protein ligase activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to oxygen-glucose deprivation; and protein ubiquitination. Localizes to several cellular components, including focal adhesion; growth cone; and membrane raft. Predicted to colocalize with flotillin complex. Used to study transient cerebral ischemia. Biomarker of congenital diaphragmatic hernia; hyperglycemia; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in acute myeloid leukemia; juvenile myelomonocytic leukemia; lung non-small cell carcinoma; and myeloid neoplasm. Orthologous to human CBL (Cbl proto-oncogene); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; epidermal growth factor/neuregulin signaling pathway; erythropoietin signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; amphetamine.
Type: protein-coding
RefSeq Status: MODEL
Also known as: c-Cbl; Cas-Br-M (murine) ecotropic retroviral transforming sequence; Casitas B-lineage lymphoma; Cbl proto-oncogene, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase CBL; LOC500985; RGD1561386; similar to CBL E3 ubiquitin protein ligase (Signal transduction protein CBL); similar to CBL E3 ubiquitin protein ligase (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto-oncogene)
Orthologs:
Homo sapiens (human) : CBL (Cbl proto-oncogene)  HGNC  Alliance
Mus musculus (house mouse) : Cbl (Casitas B-lineage lymphoma)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cbl (Cbl proto-oncogene)
Pan paniscus (bonobo/pygmy chimpanzee) : CBL (Cbl proto-oncogene)
Canis lupus familiaris (dog) : CBL (Cbl proto-oncogene)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cbl (Cbl proto-oncogene)
Sus scrofa (pig) : CBL (Cbl proto-oncogene)
Chlorocebus sabaeus (African green monkey) : CBL (Cbl proto-oncogene)
Heterocephalus glaber (naked mole-rat) : Cbl (Cbl proto-oncogene)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0848,481,256 - 48,564,775 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl848,489,036 - 48,564,722 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0847,105,710 - 47,183,347 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4847,135,357 - 47,211,889 (-)NCBIRGSC3.4rn4RGSC3.4
Celera844,074,668 - 44,158,034 (-)NCBICelera
Cytogenetic Map8q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Cbl
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1561386
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.