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Gene: Dock8 (dedicator of cytokinesis 8) Rattus norvegicus
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Symbol: Dock8
Name: dedicator of cytokinesis 8
Description: Predicted to have guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including immunological synapse formation; memory T cell proliferation; and positive regulation of establishment of T cell polarity. Predicted to localize to the cytoplasm and leading edge membrane. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in Job's syndrome and autosomal dominant non-syndromic intellectual disability 2. Orthologous to human DOCK8 (dedicator of cytokinesis 8); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: dedicator of cytokinesis protein 8; LOC499337; MGC116414; similar to dedicator of cytokinesis 8
Orthologs:
Homo sapiens (human) : DOCK8 (dedicator of cytokinesis 8)  HGNC  Alliance
Mus musculus (house mouse) : Dock8 (dedicator of cytokinesis 8)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dock8 (dedicator of cytokinesis 8)
Pan paniscus (bonobo/pygmy chimpanzee) : DOCK8 (dedicator of cytokinesis 8)
Canis lupus familiaris (dog) : DOCK8 (dedicator of cytokinesis 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dock8 (dedicator of cytokinesis 8)
Sus scrofa (pig) : DOCK8 (dedicator of cytokinesis 8)
more info ...
Allele / Splice: Dock8m1Ztm  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01242,934,685 - 243,153,472 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01250,200,507 - 250,417,771 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41228,441,384 - 228,634,717 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1219,852,410 - 220,042,463 (+)NCBICelera
Cytogenetic Map1q51NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Dock8
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1561588
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.