Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Huwe1 (HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1) Rattus norvegicus
Symbol: Huwe1
Name: HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
CRRD ID: 1561763
Description: Exhibits DNA binding activity. Predicted to be involved in several processes, including positive regulation of protein metabolic process; protein ubiquitination; and regulation of mitochondrion organization. Localizes to nucleus. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Turner type. Orthologous to human HUWE1 (HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1); PARTICIPATES IN p53 signaling pathway; INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; bisphenol A; flutamide.
Type: gene
RefSeq Status: MODEL
Also known as: HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase; hypothetical protein LOC501546; LOC501546
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0X21,474,627 - 21,603,348 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX21,499,934 - 21,598,876 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X23,634,031 - 23,635,008 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0X21,848,515 - 21,950,709 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X41,269,837 - 41,397,687 (+)NCBIRGSC3.4rn4RGSC3.4
CeleraX21,152,936 - 21,282,567 (+)NCBICelera
Cytogenetic MapXq13NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Huwe1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1561763
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.