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Gene: Sh2d1a (SH2 domain containing 1A) Rattus norvegicus
Symbol: Sh2d1a
Name: SH2 domain containing 1A
CRRD ID: 1562408
Description: Predicted to be involved in humoral immune response; negative regulation of T cell receptor signaling pathway; and positive regulation of natural killer cell mediated cytotoxicity. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in X-linked lymphoproliferative syndrome 1. Orthologous to human SH2D1A (SH2 domain containing 1A); PARTICIPATES IN measles pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; valproic acid.
Type: protein-coding
Also known as: LOC501502; RGD1562408; SH2 domain protein 1A; SH2 domain-containing protein 1A; similar to SH2 domain protein 1A (Signaling lymphocyte activation molecule-associated protein); similar to SH2 domain protein 1A (Signaling lymphocyte activation molecule-associated protein) (SLAM-associated protein) (T c ell signal transduction molecule SAP)
Homo sapiens (human) : SH2D1A (SH2 domain containing 1A)  HGNC  Alliance
Mus musculus (house mouse) : Sh2d1a (SH2 domain containing 1A)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sh2d1a (SH2 domain containing 1A)
Pan paniscus (bonobo/pygmy chimpanzee) : SH2D1A (SH2 domain containing 1A)
Canis lupus familiaris (dog) : SH2D1A (SH2 domain containing 1A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sh2d1a (SH2 domain containing 1A)
Sus scrofa (pig) : SH2D1A (SH2 domain containing 1A)
Chlorocebus sabaeus (African green monkey) : SH2D1A (SH2 domain containing 1A)
Heterocephalus glaber (naked mole-rat) : Sh2d1a (SH2 domain containing 1A)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0X128,897,053 - 128,925,408 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX128,897,181 - 128,925,407 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X128,978,818 - 129,007,045 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X2,532,295 - 2,560,524 (-)NCBIRGSC3.4rn4RGSC3.4
CeleraX120,486,695 - 120,514,918 (+)NCBICelera
Cytogenetic MapXq35NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Sh2d1a
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1562408
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.