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Gene: Skp2 (S-phase kinase associated protein 2) Rattus norvegicus
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Symbol: Skp2
Name: S-phase kinase associated protein 2
Description: Predicted to contribute to ubiquitin protein ligase activity. Involved in cellular response to cell-matrix adhesion and positive regulation of smooth muscle cell proliferation. Predicted to localize to the SCF ubiquitin ligase complex; cytosol; and nucleolus. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human SKP2 (S-phase kinase associated protein 2); PARTICIPATES IN Notch signaling pathway; p53 signaling pathway; cell cycle pathway, mitotic; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; bisphenol A; C60 fullerene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC294790; RGD1562456; S-phase kinase-associated protein 2; S-phase kinase-associated protein 2 (p45); S-phase kinase-associated protein 2, E3 ubiquitin protein ligase; similar to S-phase kinase-associated protein 2 (F-box protein Skp2) (Cyclin A/CDK2-associated protein p45) (F-box/WD-40 protein 1) (FWD1); similar to S-phase kinase-associated protein 2 (F-box protein Skp2) (F-box/WD-40 protein 1)
Orthologs:
Homo sapiens (human) : SKP2 (S-phase kinase associated protein 2)  HGNC  Alliance
Mus musculus (house mouse) : Skp2 (S-phase kinase-associated protein 2 (p45))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Skp2 (S-phase kinase associated protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SKP2 (S-phase kinase associated protein 2)
Canis lupus familiaris (dog) : SKP2 (S-phase kinase associated protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Skp2 (S-phase kinase associated protein 2)
Sus scrofa (pig) : SKP2 (S-phase kinase associated protein 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0258,506,146 - 58,534,211 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0277,593,574 - 77,621,639 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4258,769,164 - 58,797,229 (-)NCBIRGSC3.4rn4RGSC3.4
Celera253,770,002 - 53,798,066 (-)NCBICelera
Cytogenetic Map2q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Skp2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1562456
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.