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Gene: Aph1b (aph-1 homolog B, gamma secretase subunit) Rattus norvegicus
Symbol: Aph1b
Name: aph-1 homolog B, gamma secretase subunit
Description: Predicted to have endopeptidase activity. Involved in locomotory behavior. Predicted to localize to the cytoplasm; gamma-secretase complex; and integral component of plasma membrane. Human ortholog(s) of this gene implicated in coronary artery disease. Orthologous to human APH1B (aph-1 homolog B, gamma-secretase subunit); PARTICIPATES IN Notch signaling pathway; syndecan signaling pathway; Alzheimer's disease pathway; INTERACTS WITH (RS)-amphetamine; 2,6-dinitrotoluene; 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one.
Type: protein-coding
Also known as: anterior pharynx defective 1 homolog B; anterior pharynx defective 1 homolog B (C. elegans); anterior pharynx defective 1b homolog; anterior pharynx defective 1b homolog (C. elegans); APH-1B'; APH1B gamma secretase subunit; gamma-secretase subunit APH-1B; presenilin stabilization factor-like; similar to anterior pharynx defective 1b homolog
Homo sapiens (human) : APH1B (aph-1 homolog B, gamma-secretase subunit)  HGNC  Alliance
Mus musculus (house mouse) : Aph1b (aph1 homolog B, gamma secretase subunit)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aph1b (aph-1 homolog B, gamma-secretase subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : APH1B (aph-1 homolog B, gamma-secretase subunit)
Canis lupus familiaris (dog) : APH1B (aph-1 homolog B, gamma-secretase subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aph1b (aph-1 homolog B, gamma-secretase subunit)
Sus scrofa (pig) : APH1B (aph-1 homolog B, gamma-secretase subunit)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0872,508,008 - 72,598,921 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0876,942,439 - 76,963,484 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4871,122,681 - 71,143,726 (-)NCBIRGSC3.4rn4RGSC3.4
Celera874,251,130 - 74,264,693 (+)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
More on Aph1b
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1562468
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.