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Gene: Gjc2 (gap junction protein, gamma 2) Rattus norvegicus
Symbol: Gjc2
Name: gap junction protein, gamma 2
Description: Predicted to have gap junction channel activity involved in cell communication by electrical coupling. Involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle; nervous system development; and positive regulation of calcium ion transmembrane transport. Localizes to several cellular components, including paranode region of axon; perikaryon; and proximal neuron projection. Biomarker of Parkinson's disease. Human ortholog(s) of this gene implicated in hereditary lymphedema IC; hereditary spastic paraplegia 44; hypomyelinating leukodystrophy 2; and lymphedema. Orthologous to human GJC2 (gap junction protein gamma 2); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: connexin-47; Cx47; gap junction alpha-12 protein; gap junction gamma-2 protein; gap junction membrane channel protein alpha 12; gap junction protein, alpha 12; gap junction protein, alpha 12, 47kDa; Gja12
Homo sapiens (human) : GJC2 (gap junction protein gamma 2)  HGNC  Alliance
Mus musculus (house mouse) : Gjc2 (gap junction protein, gamma 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gjc2 (gap junction protein gamma 2)
Pan paniscus (bonobo/pygmy chimpanzee) : GJC2 (gap junction protein gamma 2)
Canis lupus familiaris (dog) : GJC2 (gap junction protein gamma 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gjc2 (gap junction protein gamma 2)
Sus scrofa (pig) : GJC2 (gap junction protein gamma 2)
Chlorocebus sabaeus (African green monkey) : GJC2 (gap junction protein gamma 2)
Heterocephalus glaber (naked mole-rat) : Gjc2 (gap junction protein gamma 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01045,526,740 - 45,535,520 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1045,526,745 - 45,534,570 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01045,282,830 - 45,291,628 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41045,480,937 - 45,488,651 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1043,225,920 - 43,233,731 (-)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Gjc2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1562712
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.