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Gene: Sppl3 (signal peptide peptidase like 3) Rattus norvegicus
Symbol: Sppl3
Name: signal peptide peptidase like 3
CRRD ID: 1562826
Description: Predicted to have aspartic endopeptidase activity, intramembrane cleaving and protein homodimerization activity. Predicted to be involved in several processes, including T cell receptor signaling pathway; positive regulation of calcineurin-NFAT signaling cascade; and proteolysis. Predicted to localize to several cellular components, including bounding membrane of organelle; integral component of endoplasmic reticulum membrane; and rough endoplasmic reticulum. Orthologous to human SPPL3 (signal peptide peptidase like 3); INTERACTS WITH 2,5-hexanedione; bisphenol A; oxaliplatin.
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOC360822; RGD1562826; signal peptide peptidase 3; signal peptide peptidase-like 3; signal peptide peptidase-like 3, pseudogene 1; similar to Hypothetical protein MGC75937; Sppl3-ps1
Homo sapiens (human) : SPPL3 (signal peptide peptidase like 3)  HGNC  Alliance
Mus musculus (house mouse) : Sppl3 (signal peptide peptidase 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sppl3 (signal peptide peptidase like 3)
Pan paniscus (bonobo/pygmy chimpanzee) : SPPL3 (signal peptide peptidase like 3)
Canis lupus familiaris (dog) : SPPL3 (signal peptide peptidase like 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sppl3 (signal peptide peptidase like 3)
Sus scrofa (pig) : SPPL3 (signal peptide peptidase like 3)
Chlorocebus sabaeus (African green monkey) : SPPL3 (signal peptide peptidase like 3)
Heterocephalus glaber (naked mole-rat) : Sppl3 (signal peptide peptidase like 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01247,276,485 - 47,360,552 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1247,276,476 - 47,360,507 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01249,071,961 - 49,156,613 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41242,788,576 - 42,882,650 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1243,134,305 - 43,170,708 (-)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Sppl3
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1562826
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.