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Gene: Was (WASP actin nucleation promoting factor) Rattus norvegicus
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Symbol: Was
Name: WASP actin nucleation promoting factor
Description: Predicted to have several functions, including SH3 domain binding activity; actin filament binding activity; and enzyme binding activity. Predicted to be involved in several processes, including actin cytoskeleton organization; positive regulation of nucleobase-containing compound metabolic process; and regulation of actin filament organization. Predicted to localize to several cellular components, including actin cytoskeleton; phagocytic vesicle; and site of double-strand break. Human ortholog(s) of this gene implicated in Wiskott-Aldrich syndrome and severe congenital neutropenia. Orthologous to human WAS (WASP actin nucleation promoting factor); PARTICIPATES IN chemokine mediated signaling pathway; Fc gamma receptor mediated signaling pathway; INTERACTS WITH acetamide; bisphenol A; (Z)-3-butylidenephthalide (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: WASP; Wiskott-Aldrich syndrome; Wiskott-Aldrich syndrome homolog; Wiskott-Aldrich syndrome homolog (human); Wiskott-Aldrich syndrome protein
Orthologs:
Homo sapiens (human) : WAS (WASP actin nucleation promoting factor)  HGNC  Alliance
Mus musculus (house mouse) : Was (Wiskott-Aldrich syndrome)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Was (WASP actin nucleation promoting factor)
Pan paniscus (bonobo/pygmy chimpanzee) : WAS (WASP actin nucleation promoting factor)
Canis lupus familiaris (dog) : WAS (WASP actin nucleation promoting factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Was (WASP actin nucleation promoting factor)
Sus scrofa (pig) : WAS (WASP actin nucleation promoting factor)
Chlorocebus sabaeus (African green monkey) : WAS (WASP actin nucleation promoting factor)
Heterocephalus glaber (naked mole-rat) : Was (WASP actin nucleation promoting factor)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0X15,155,246 - 15,164,099 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,155,230 - 15,164,105 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X15,938,008 - 15,946,861 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X26,436,292 - 26,444,997 (+)NCBIRGSC3.4rn4RGSC3.4
CeleraX14,489,816 - 14,498,509 (+)NCBICelera
Cytogenetic MapXq12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Was
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1563567
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.