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Gene: Irak1 (interleukin-1 receptor-associated kinase 1) Rattus norvegicus
Symbol: Irak1
Name: interleukin-1 receptor-associated kinase 1
Description: Exhibits heat shock protein binding activity and protein kinase activity. Involved in several processes, including JNK cascade; cellular response to lipopolysaccharide; and positive regulation of smooth muscle cell proliferation. Localizes to membrane. Biomarker of brain ischemia and cognitive disorder. Human ortholog(s) of this gene implicated in ankylosing spondylitis; diffuse scleroderma; psoriatic arthritis; and squamous cell carcinoma. Orthologous to human IRAK1 (interleukin 1 receptor associated kinase 1); PARTICIPATES IN interleukin-1 signaling pathway; Toll-like receptor signaling pathway; apoptotic cell death pathway; INTERACTS WITH 17alpha-ethynylestradiol; acrylamide; bisphenol A.
Type: protein-coding
Also known as: LOC363520; RGD1563841; similar to interleukin-1 receptor associated kinase 1 splice form 3
Homo sapiens (human) : IRAK1 (interleukin 1 receptor associated kinase 1)  HGNC  Alliance
Mus musculus (house mouse) : Irak1 (interleukin-1 receptor-associated kinase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Irak1 (interleukin 1 receptor associated kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : IRAK1 (interleukin 1 receptor associated kinase 1)
Canis lupus familiaris (dog) : IRAK1 (interleukin 1 receptor associated kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Irak1 (interleukin 1 receptor associated kinase 1)
Sus scrofa (pig) : IRAK1 (interleukin 1 receptor associated kinase 1)
Chlorocebus sabaeus (African green monkey) : IRAK1 (interleukin 1 receptor associated kinase 1)
Heterocephalus glaber (naked mole-rat) : Irak1 (interleukin 1 receptor associated kinase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0X156,716,469 - 156,726,367 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX156,716,604 - 156,725,977 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01152,464,303 - 152,474,397 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X159,960,184 - 159,969,180 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1136,116,523 - 136,125,519 (+)NCBICelera
Cytogenetic MapXq37NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Irak1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1563841
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2020-03-31
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.