Gene: Ndp (norrin cystine knot growth factor NDP) Rattus norvegicus
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Symbol: Ndp
Name: norrin cystine knot growth factor NDP
Description: Predicted to have cytokine activity, frizzled binding activity, and protein homodimerization activity; involved in decidualization; predicted to localize to the cell surface, collagen-containing extracellular matrix, and extracellular space; orthologous to human NDP (norrin cystine knot growth factor NDP); PARTICIPATES IN Wnt signaling, canonical pathway; INTERACTS WITH acrylamide; bisphenol A; vinclozolin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC363443; NDP, norrin cystine knot growth factor; Ndph; Norrie disease (pseudoglioma); Norrie disease (pseudoglioma) (human); Norrie disease homolog; Norrie disease homolog (human); norrin; RGD1563968; similar to NDP
Orthologs:
Homo sapiens (human) : NDP (norrin cystine knot growth factor NDP)  HGNC  Alliance
Mus musculus (house mouse) : Ndp (Norrie disease (pseudoglioma) (human))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ndp (norrin cystine knot growth factor NDP)
Pan paniscus (bonobo/pygmy chimpanzee) : NDP (norrin cystine knot growth factor NDP)
Canis lupus familiaris (dog) : NDP (norrin cystine knot growth factor NDP)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ndp (norrin cystine knot growth factor NDP)
Sus scrofa (pig) : NDP (norrin cystine knot growth factor NDP)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Note: Ndp was annotated incorrectly on Rnor_6.0 (Annotation Release 105) but correctly on Rn_Celera. Annotation of Ndp on Rn_Celera is supported by synteny with human and mouse and this locus is instead annotated as LOC100909913 on Rnor_6.0. Additionally, the locus annotated as Ndp on Rnor_6.0 represents a duplicate placement of this locus and this annotation lacks support by the syntenic region in mouse and human. BLASTing Ndp NM_001108814.1 against the rat genome (Annotation Release 105) shows best hits to the locations where both Ndp and LOC100909913 are annotated on Rnor_6.0 (NC_005120.4, 100% identity at each location) and where Ndp is annotated on Rn_Celera (AC_000089.1, 100% identity). BLASTing LOC100909913 XM_003751998.3 against the rat genome (Annotation Release 105) shows best hits to the locations where both Ndp and LOC100909913 are annotated on Rnor_6.0 (NC_005120.4, 100% identity at each location) and where Ndp is annotated on Rn_Celera (AC_000089.1, 100% identity). 2-sequence BLAST of Ndp NM_001108814.1 against LOC100909913 XM_003751998.3 shows high sequence identity (100% coverage, 100% identity). 2-sequence BLAST of Ndp underlying component AC097257.7 against the LOC100909913 underlying component AABR07073515.1 (both on Rnor_6.0) shows high sequence identity (99%) across ~67 kb. [26 Mar 2015]
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0X6,791,090 - 6,815,586 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X7,591,522 - 7,615,969 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X17,416,946 - 17,441,393 (+)NCBIRGSC3.4rn4RGSC3.4
CeleraX6,291,036 - 6,315,505 (+)NCBICelera
Cytogenetic MapXq11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Ndp
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1563968
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.