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Gene: Scube2 (signal peptide, CUB domain and EGF like domain containing 2) Rattus norvegicus
Symbol: Scube2
Name: signal peptide, CUB domain and EGF like domain containing 2
Description: Predicted to have hedgehog family protein binding activity. Predicted to be involved in several processes, including positive regulation of chondrocyte proliferation; positive regulation of osteoblast differentiation; and positive regulation of smoothened signaling pathway. Predicted to localize to the cell surface and extracellular space. Orthologous to human SCUBE2 (signal peptide, CUB domain and EGF like domain containing 2); INTERACTS WITH endosulfan; 17alpha-ethynylestradiol (ortholog); 17beta-estradiol (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOC499241; RGD1563998; Scube2-ps1; signal peptide, CUB and EGF-like domain-containing protein 2; signal peptide, CUB domain, EGF-like 2; signal peptide, CUB domain, EGF-like 2, pseudogene 1; similar to Cegp1 protein
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01174,428,056 - 174,495,356 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01181,412,988 - 181,479,843 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41167,423,473 - 167,490,273 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1161,729,792 - 161,797,481 (-)NCBICelera
Cytogenetic Map1q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Scube2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1563998
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.