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Gene: Dock2 (dedicator of cytokinesis 2) Rattus norvegicus
Symbol: Dock2
Name: dedicator of cytokinesis 2
Description: Predicted to have GTPase activator activity; Rac guanyl-nucleotide exchange factor activity; and T cell receptor binding activity. Predicted to be involved in several processes, including T cell activation; membrane raft polarization; and myeloid dendritic cell activation involved in immune response. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human DOCK2 (dedicator of cytokinesis 2); PARTICIPATES IN chemokine mediated signaling pathway; Fc gamma receptor mediated signaling pathway; INTERACTS WITH 2,6-dinitrotoluene; 3-chloropropane-1,2-diol; bisphenol A.
Type: protein-coding
RefSeq Status: MODEL
Also known as: dedicator of cytokinesis protein 2
Homo sapiens (human) : DOCK2 (dedicator of cytokinesis 2)  HGNC  Alliance
Mus musculus (house mouse) : Dock2 (dedicator of cyto-kinesis 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dock2 (dedicator of cytokinesis 2)
Pan paniscus (bonobo/pygmy chimpanzee) : DOCK2 (dedicator of cytokinesis 2)
Canis lupus familiaris (dog) : DOCK2 (dedicator of cytokinesis 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dock2 (dedicator of cytokinesis 2)
Sus scrofa (pig) : DOCK2 (dedicator of cytokinesis 2)
Chlorocebus sabaeus (African green monkey) : DOCK2 (dedicator of cytokinesis 2)
Heterocephalus glaber (naked mole-rat) : Dock2 (dedicator of cytokinesis 2)
more info ...
Related Pseudogenes: Dock2-ps1  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01019,181,512 - 19,603,171 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01019,060,032 - 19,481,150 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41019,207,499 - 19,660,353 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1018,459,930 - 18,875,791 (-)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Dock2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1564189
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.