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Gene: Shb (SH2 domain containing adaptor protein B) Rattus norvegicus
Symbol: Shb
Name: SH2 domain containing adaptor protein B
Description: Predicted to have phosphotyrosine residue binding activity. Predicted to be involved in several processes, including hematopoietic stem cell proliferation; negative regulation of oocyte maturation; and positive regulation of immune response. Predicted to localize to cytoplasmic ribonucleoprotein granule; cytosol; and nucleoplasm. Orthologous to human SHB (SH2 domain containing adaptor protein B); PARTICIPATES IN platelet-derived growth factor signaling pathway; vascular endothelial growth factor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOC362513; RGD1565350; SH2 domain-containing adapter protein B; similar to Shb protein; Src homology 2 domain containing adaptor protein B
Homo sapiens (human) : SHB (SH2 domain containing adaptor protein B)  HGNC  Alliance
Mus musculus (house mouse) : Shb (src homology 2 domain-containing transforming protein B)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Shb (SH2 domain containing adaptor protein B)
Pan paniscus (bonobo/pygmy chimpanzee) : SHB (SH2 domain containing adaptor protein B)
Canis lupus familiaris (dog) : SHB (SH2 domain containing adaptor protein B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Shb (SH2 domain containing adaptor protein B)
Sus scrofa (pig) : SHB (SH2 domain containing adaptor protein B)
Chlorocebus sabaeus (African green monkey) : SHB (SH2 domain containing adaptor protein B)
Heterocephalus glaber (naked mole-rat) : Shb (SH2 domain containing adaptor protein B)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0560,970,650 - 61,077,881 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl560,971,257 - 61,077,627 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0565,479,290 - 65,587,205 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4561,983,643 - 62,090,620 (-)NCBIRGSC3.4rn4RGSC3.4
Celera558,246,193 - 58,353,269 (-)NCBICelera
Cytogenetic Map5q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Shb
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1565350
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.