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Gene: Hlcs (holocarboxylase synthetase) Rattus norvegicus
Symbol: Hlcs
Name: holocarboxylase synthetase
CRRD ID: 1565360
Description: Exhibits biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity and identical protein binding activity. Involved in response to biotin. Predicted to localize to chromatin; cytosol; and nuclear periphery. Human ortholog(s) of this gene implicated in holocarboxylase synthetase deficiency. Orthologous to human HLCS (holocarboxylase synthetase); PARTICIPATES IN biotin metabolic pathway; biotinidase deficiency pathway; holocarboxylase synthetase deficiency pathway; INTERACTS WITH 6-propyl-2-thiouracil; amphetamine; bisphenol A.
Type: protein-coding
RefSeq Status: MODEL
Also known as: biotin--protein ligase; holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase); holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase); holocarboxylase synthetase (biotin-(proprionyl-Coenzyme A-carboxylase (ATP-hydrolysing)) ligase); LOC288240; RGD1565360; similar to homolog of Human holocarboxylase synthetase gene HLCS
Homo sapiens (human) : HLCS (holocarboxylase synthetase)  HGNC  Alliance
Mus musculus (house mouse) : Hlcs (holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hlcs (holocarboxylase synthetase)
Pan paniscus (bonobo/pygmy chimpanzee) : HLCS (holocarboxylase synthetase)
Canis lupus familiaris (dog) : HLCS (holocarboxylase synthetase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hlcs (holocarboxylase synthetase)
Sus scrofa (pig) : HLCS (holocarboxylase synthetase)
Chlorocebus sabaeus (African green monkey) : HLCS (holocarboxylase synthetase)
Heterocephalus glaber (naked mole-rat) : Hlcs (holocarboxylase synthetase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01134,357,372 - 34,537,798 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1134,352,287 - 34,526,931 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01137,944,545 - 38,122,589 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41134,382,010 - 34,539,032 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1134,813,786 - 34,994,033 (+)NCBICelera
Cytogenetic Map11q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Hlcs
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1565360
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.