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Gene: Setx (senataxin) Rattus norvegicus
Symbol: Setx
Name: senataxin
Description: Predicted to have RNA binding activity; identical protein binding activity; and transcription termination site sequence-specific DNA binding activity. Predicted to be involved in several processes, including intracellular signal transduction; nucleic acid metabolic process; and positive regulation of RNA metabolic process. Predicted to localize to several cellular components, including the growth cone; intercellular bridge; and nuclear lumen. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 4 and ataxia with oculomotor apraxia type 2. Orthologous to human SETX (senataxin); INTERACTS WITH amphetamine; bisphenol A; DDT.
Type: protein-coding
RefSeq Status: MODEL
Also known as: DEAxQ-box helicase; LOC362096; LOW QUALITY PROTEIN: probable helicase senataxin; probable helicase senataxin; RGD1565575; similar to senataxin; tRNA splicing endonuclease regulator 1
Homo sapiens (human) : SETX (senataxin)  HGNC  Alliance
Mus musculus (house mouse) : Setx (senataxin)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Setx (senataxin)
Pan paniscus (bonobo/pygmy chimpanzee) : SETX (senataxin)
Canis lupus familiaris (dog) : SETX (senataxin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Setx (senataxin)
Sus scrofa (pig) : SETX (senataxin)
Chlorocebus sabaeus (African green monkey) : SETX (senataxin)
Heterocephalus glaber (naked mole-rat) : Setx (senataxin)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.037,680,430 - 7,731,815 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl37,686,503 - 7,730,539 (+)Ensembl
Rnor_5.0313,029,002 - 13,080,379 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.438,113,749 - 8,156,463 (+)NCBIRGSC3.4rn4RGSC3.4
Celera37,210,020 - 7,259,874 (+)NCBICelera
Cytogenetic Map3p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Setx
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1565575
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.