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Gene: H2ax (H2A.X variant histone) Rattus norvegicus
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Symbol: H2ax
Name: H2A.X variant histone
Description: Predicted to have damaged DNA binding activity; enzyme binding activity; and histone binding activity. Involved in several processes, including cellular response to gamma radiation; cellular senescence; and cerebral cortex development. Localizes to the nucleus. Predicted to colocalize with the chromosome, telomeric region. Used to study hypertension; status epilepticus; and transient cerebral ischemia. Biomarker of liver benign neoplasm. Orthologous to human H2AFX (H2A histone family member X); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; histone modification pathway; systemic lupus erythematosus pathway; INTERACTS WITH (+)-catechin (ortholog); (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE (ortholog); (S)-nicotine (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: H2A histone family, member X; H2afx; LOC500987; RGD1566119; similar to Histone H2A.x (H2a/x)
Orthologs:
Homo sapiens (human) : H2AX (H2A.X variant histone)  HGNC  Alliance
Mus musculus (house mouse) : H2ax (H2A.X variant histone)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102025775 (histone H2AX)
Pan paniscus (bonobo/pygmy chimpanzee) : LOC100994157 (histone H2AX)
Canis lupus familiaris (dog) : LOC489372 (histone H2AX)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101966907 (histone H2AX)
Sus scrofa (pig) : LOC100522201 (histone H2AX)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0848,665,652 - 48,666,981 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0847,284,623 - 47,285,952 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4847,312,609 - 47,313,938 (+)NCBIRGSC3.4rn4RGSC3.4
Celera844,258,161 - 44,259,490 (+)NCBICelera
Cytogenetic Map8q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on H2ax
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1566119
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2019-09-24
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.