Gene: Tcf7l2 (transcription factor 7 like 2) Rattus norvegicus
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Symbol: Tcf7l2
Name: transcription factor 7 like 2
Description: Predicted to have several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor binding activity, and RNA polymerase II proximal promoter sequence-specific DNA binding activity; predicted to be involved in several processes, including animal organ development, nervous system development, and regulation of cellular biosynthetic process; predicted to localize to the cytosol, intracellular organelle, and protein-DNA complex; biomarker of type 2 diabetes mellitus; orthologous to human TCF7L2 (transcription factor 7 like 2); PARTICIPATES IN altered Wnt signaling, canonical pathway; pancreatic cancer pathway; Wnt signaling, canonical pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 17beta-estradiol; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC679869; similar to transcription factor 7-like 2, T-cell specific, HMG-box; transcription factor 7-like 2; transcription factor 7-like 2 (T-cell specific, HMG-box); transcription factor 7-like 2, T-cell specific, HMG-box
Orthologs:
Homo sapiens (human) : TCF7L2 (transcription factor 7 like 2)  HGNC  Alliance
Mus musculus (house mouse) : Tcf7l2 (transcription factor 7 like 2, T cell specific, HMG box)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tcf7l2 (transcription factor 7 like 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TCF7L2 (transcription factor 7 like 2)
Canis lupus familiaris (dog) : TCF7L2 (transcription factor 7 like 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tcf7l2 (transcription factor 7 like 2)
Sus scrofa (pig) : TCF7L2 (transcription factor 7 like 2)
more info ...
Allele / Splice: Tcf7l2em1Mcwi  
Genetic Models: SS-Tcf7l2em1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01276,686,911 - 276,730,517 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01283,387,566 - 283,412,364 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01284,077,353 - 284,118,928 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41262,031,823 - 262,226,710 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1250,490,882 - 250,683,257 (+)NCBICelera
Cytogenetic Map1q55NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Tcf7l2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1583621
Created: 2006-11-19
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.