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Gene: Top2b (DNA topoisomerase II beta) Rattus norvegicus
Symbol: Top2b
Name: DNA topoisomerase II beta
Description: Exhibits ribonucleoprotein complex binding activity. Involved in several processes, including cellular response to ATP; cellular response to hydrogen peroxide; and positive regulation of double-strand break repair via nonhomologous end joining. Localizes to the nucleolus. Predicted to colocalize with the heterochromatin. Orthologous to human TOP2B (DNA topoisomerase II beta); PARTICIPATES IN doxorubicin pharmacodynamics pathway; doxorubicin response pathway; etoposide pharmacodynamics pathway; INTERACTS WITH (+)-dexrazoxane; (RS)-amphetamine; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE.
Type: protein-coding
Also known as: DNA topoisomerase 2-beta; LOC361100; similar to topoisomerase (DNA) II beta; topoisomerase (DNA) II beta; topoisomerase II beta
Homo sapiens (human) : TOP2B (DNA topoisomerase II beta)  HGNC  Alliance
Mus musculus (house mouse) : Top2b (topoisomerase (DNA) II beta)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Top2b (DNA topoisomerase II beta)
Pan paniscus (bonobo/pygmy chimpanzee) : TOP2B (DNA topoisomerase II beta)
Canis lupus familiaris (dog) : TOP2B (DNA topoisomerase II beta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Top2b (DNA topoisomerase II beta)
Sus scrofa (pig) : TOP2B (DNA topoisomerase II beta)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01510,262,972 - 10,319,741 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01514,308,369 - 14,366,373 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera159,095,127 - 9,153,091 (-)NCBICelera
Cytogenetic Map15p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Top2b
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1586156
Created: 2006-11-19
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.