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Gene: Top2b (DNA topoisomerase II beta) Rattus norvegicus
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Symbol: Top2b
Name: DNA topoisomerase II beta
Description: Exhibits ribonucleoprotein complex binding activity. Involved in several processes, including cellular response to ATP; cellular response to hydrogen peroxide; and positive regulation of double-strand break repair via nonhomologous end joining. Localizes to the nucleolus. Predicted to colocalize with the heterochromatin. Orthologous to human TOP2B (DNA topoisomerase II beta); PARTICIPATES IN doxorubicin pharmacodynamics pathway; doxorubicin response pathway; etoposide pharmacodynamics pathway; INTERACTS WITH (+)-dexrazoxane; (RS)-amphetamine; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: DNA topoisomerase 2-beta; LOC361100; similar to topoisomerase (DNA) II beta; topoisomerase (DNA) II beta; topoisomerase II beta
Orthologs:
Homo sapiens (human) : TOP2B (DNA topoisomerase II beta)  HGNC  Alliance
Mus musculus (house mouse) : Top2b (topoisomerase (DNA) II beta)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Top2b (DNA topoisomerase II beta)
Pan paniscus (bonobo/pygmy chimpanzee) : TOP2B (DNA topoisomerase II beta)
Canis lupus familiaris (dog) : TOP2B (DNA topoisomerase II beta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Top2b (DNA topoisomerase II beta)
Sus scrofa (pig) : TOP2B (DNA topoisomerase II beta)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01510,262,972 - 10,319,741 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01514,308,369 - 14,366,373 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera159,095,127 - 9,153,091 (-)NCBICelera
Cytogenetic Map15p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Top2b
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1586156
Created: 2006-11-19
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.