Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Tmem67 (transmembrane protein 67) Rattus norvegicus
Symbol: Tmem67
Name: transmembrane protein 67
Description: Exhibits misfolded protein binding activity. Involved in several processes, including photoreceptor cell outer segment organization; positive regulation of ERAD pathway; and regulation of organelle organization. Localizes to cytoplasmic vesicle membrane; endoplasmic reticulum membrane; and plasma membrane. Colocalizes with axoneme. Used to study Meckel syndrome 3; autosomal recessive polycystic kidney disease; communicating hydrocephalus; and hydrocephalus. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome (multiple); COACH syndrome; Joubert syndrome 6; Meckel syndrome 3; and nephronophthisis 11. Orthologous to human TMEM67 (transmembrane protein 67); INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: LOC313067; Meckel syndrome type 3 protein homolog; Meckelin; Mks3; similar to transmembrane protein 67; Wistar polycystic kidney; Wpk
Homo sapiens (human) : TMEM67 (transmembrane protein 67)  HGNC  Alliance
Mus musculus (house mouse) : Tmem67 (transmembrane protein 67)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tmem67 (transmembrane protein 67)
Pan paniscus (bonobo/pygmy chimpanzee) : TMEM67 (transmembrane protein 67)
Canis lupus familiaris (dog) : TMEM67 (transmembrane protein 67)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tmem67 (transmembrane protein 67)
Sus scrofa (pig) : TMEM67 (transmembrane protein 67)
Chlorocebus sabaeus (African green monkey) : TMEM67 (transmembrane protein 67)
Heterocephalus glaber (naked mole-rat) : Tmem67 (transmembrane protein 67)
more info ...
Allele / Splice: Tmem67wpk  
Genetic Models: Wpk Wpk +/- Wpk -/-
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0525,666,138 - 25,721,056 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl525,666,137 - 25,721,072 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0530,371,964 - 30,424,943 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4526,324,625 - 26,377,531 (-)NCBIRGSC3.4rn4RGSC3.4
Celera524,866,083 - 24,918,920 (-)NCBICelera
Cytogenetic Map5q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Tmem67
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1586167
Created: 2006-11-19
Species: Rattus norvegicus
Last Modified: 2020-03-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.