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Gene: Tmem67 (transmembrane protein 67) Rattus norvegicus
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Symbol: Tmem67
Name: transmembrane protein 67
Description: Exhibits misfolded protein binding activity. Involved in several processes, including photoreceptor cell outer segment organization; positive regulation of ERAD pathway; and regulation of organelle organization. Localizes to cytoplasmic vesicle membrane; endoplasmic reticulum membrane; and plasma membrane. Colocalizes with axoneme. Used to study Meckel syndrome 3; autosomal recessive polycystic kidney disease; communicating hydrocephalus; and hydrocephalus. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome (multiple); COACH syndrome; Joubert syndrome 6; Meckel syndrome 3; and nephronophthisis 11. Orthologous to human TMEM67 (transmembrane protein 67); INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: LOC313067; Meckel syndrome type 3 protein homolog; Meckelin; Mks3; similar to transmembrane protein 67; Wistar polycystic kidney; Wpk
Orthologs:
Homo sapiens (human) : TMEM67 (transmembrane protein 67)  HGNC  Alliance
Mus musculus (house mouse) : Tmem67 (transmembrane protein 67)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tmem67 (transmembrane protein 67)
Pan paniscus (bonobo/pygmy chimpanzee) : TMEM67 (transmembrane protein 67)
Canis lupus familiaris (dog) : TMEM67 (transmembrane protein 67)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tmem67 (transmembrane protein 67)
Sus scrofa (pig) : TMEM67 (transmembrane protein 67)
Chlorocebus sabaeus (African green monkey) : TMEM67 (transmembrane protein 67)
Heterocephalus glaber (naked mole-rat) : Tmem67 (transmembrane protein 67)
more info ...
Allele / Splice: Tmem67wpk  
Genetic Models: Wpk Wpk +/- Wpk -/-
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0525,666,138 - 25,721,056 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl525,666,137 - 25,721,072 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0530,371,964 - 30,424,943 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4526,324,625 - 26,377,531 (-)NCBIRGSC3.4rn4RGSC3.4
Celera524,866,083 - 24,918,920 (-)NCBICelera
Cytogenetic Map5q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Tmem67
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1586167
Created: 2006-11-19
Species: Rattus norvegicus
Last Modified: 2020-03-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.