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Gene: Sorbs1 (sorbin and SH3 domain containing 1) Rattus norvegicus
Symbol: Sorbs1
Name: sorbin and SH3 domain containing 1
Description: Exhibits insulin receptor binding activity and ubiquitin protein ligase binding activity. Involved in several processes, including response to activity; response to insulin; and response to monosodium L-glutamate. Localizes to the insulin receptor complex. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human SORBS1 (sorbin and SH3 domain containing 1); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; insulin signaling pathway; Rho/Rac/Cdc42 mediated signaling pathway; INTERACTS WITH 1,3-dinitrobenzene; 17beta-estradiol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: MODEL
Also known as: CAP; Cbl associated protein; LOC686098; ponsin; SH3P12; similar to sorbin and SH3 domain containing 1 isoform 3; sorbin and SH3 domain-containing protein 1
Homo sapiens (human) : SORBS1 (sorbin and SH3 domain containing 1)  HGNC  Alliance
Mus musculus (house mouse) : Sorbs1 (sorbin and SH3 domain containing 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sorbs1 (sorbin and SH3 domain containing 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SORBS1 (sorbin and SH3 domain containing 1)
Canis lupus familiaris (dog) : SORBS1 (sorbin and SH3 domain containing 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sorbs1 (sorbin and SH3 domain containing 1)
Sus scrofa (pig) : SORBS1 (sorbin and SH3 domain containing 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01259,373,921 - 259,502,108 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01266,817,755 - 267,037,940 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41245,419,532 - 245,527,846 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1234,954,631 - 235,082,791 (-)NCBICelera
Cytogenetic Map1q54NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Sorbs1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1586598
Created: 2006-11-19
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.