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Gene: Sorbs1 (sorbin and SH3 domain containing 1) Rattus norvegicus
Symbol: Sorbs1
Name: sorbin and SH3 domain containing 1
CRRD ID: 1586598
Description: Exhibits insulin receptor binding activity and ubiquitin protein ligase binding activity. Involved in several processes, including response to activity; response to insulin; and response to monosodium L-glutamate. Localizes to insulin receptor complex. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human SORBS1 (sorbin and SH3 domain containing 1); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; insulin signaling pathway; Rho/Rac/Cdc42 mediated signaling pathway; INTERACTS WITH 1,3-dinitrobenzene; 17beta-estradiol; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: MODEL
Also known as: CAP; Cbl associated protein; LOC686098; ponsin; SH3P12; similar to sorbin and SH3 domain containing 1 isoform 3; sorbin and SH3 domain-containing protein 1
Homo sapiens (human) : SORBS1 (sorbin and SH3 domain containing 1)  HGNC  Alliance
Mus musculus (house mouse) : Sorbs1 (sorbin and SH3 domain containing 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sorbs1 (sorbin and SH3 domain containing 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SORBS1 (sorbin and SH3 domain containing 1)
Canis lupus familiaris (dog) : SORBS1 (sorbin and SH3 domain containing 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sorbs1 (sorbin and SH3 domain containing 1)
Sus scrofa (pig) : SORBS1 (sorbin and SH3 domain containing 1)
Chlorocebus sabaeus (African green monkey) : SORBS1 (sorbin and SH3 domain containing 1)
Heterocephalus glaber (naked mole-rat) : Sorbs1 (sorbin and SH3 domain containing 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01259,373,921 - 259,502,108 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1259,376,933 - 259,484,569 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01266,817,755 - 267,037,940 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41245,419,532 - 245,527,846 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1234,954,631 - 235,082,791 (-)NCBICelera
Cytogenetic Map1q54NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Sorbs1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1586598
Created: 2006-11-19
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.