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Gene: Ryr1 (ryanodine receptor 1) Rattus norvegicus
Symbol: Ryr1
Name: ryanodine receptor 1
Description: Exhibits ryanodine-sensitive calcium-release channel activity. Involved in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; response to estradiol; and response to purine-containing compound. Localizes to extrinsic component of cytoplasmic side of plasma membrane; sarcolemma; and sarcoplasmic reticulum. Human ortholog(s) of this gene implicated in central core myopathy and malignant hyperthermia. Orthologous to human RYR1 (ryanodine receptor 1); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOC686059; LOW QUALITY PROTEIN: ryanodine receptor 1; ryanodine receptor 1 (skeletal); ryanodine receptor 1, skeletal muscle; ryanodine receptor 1-like; ryanodine receptor 1-like, skeletal muscle; RYR-1; Ryr1l; similar to ryanodine receptor 1 (skeletal); skeletal muscle calcium release channel; skeletal muscle ryanodine receptor; skeletal muscle-type ryanodine receptor; type 1 ryanodine receptor
Homo sapiens (human) : RYR1 (ryanodine receptor 1)  HGNC  Alliance
Mus musculus (house mouse) : Ryr1 (ryanodine receptor 1, skeletal muscle)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ryr1 (ryanodine receptor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : RYR1 (ryanodine receptor 1)
Canis lupus familiaris (dog) : RYR1 (ryanodine receptor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ryr1 (ryanodine receptor 1)
Sus scrofa (pig) : RYR1 (ryanodine receptor 1)
Chlorocebus sabaeus (African green monkey) : RYR1 (ryanodine receptor 1)
Heterocephalus glaber (naked mole-rat) : Ryr1 (ryanodine receptor 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0187,959,596 - 88,066,252 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl187,959,712 - 88,066,101 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0189,135,622 - 89,241,311 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4184,116,098 - 84,254,503 (-)NCBIRGSC3.4rn4RGSC3.4
Celera178,682,691 - 78,812,242 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Ryr1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1586637
Created: 2006-11-19
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.