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Gene: Nnt (nicotinamide nucleotide transhydrogenase) Rattus norvegicus
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Symbol: Nnt
Name: nicotinamide nucleotide transhydrogenase
Description: Predicted to have NAD binding activity; NAD(P)+ transhydrogenase activity; and NADP binding activity. Involved in several processes, including cell redox homeostasis; oxygen homeostasis; and positive regulation of hydrogen peroxide catabolic process. Localizes to the mitochondrion. Biomarker of obesity. Human ortholog(s) of this gene implicated in adrenal gland disease. Orthologous to human NNT (nicotinamide nucleotide transhydrogenase); PARTICIPATES IN niacin metabolic pathway; nicotinamide adenine dinucleotide metabolic pathway; monoterpenoid biosynthetic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,2,2-tetramine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: MGC109126; NAD(P) transhydrogenase, mitochondrial; nicotinamide nucleotide transhydrogenase (mapped); Nicotinamide nucleotide transhydrogenase (NAD(P)+ transhydrogenase); Nnt_mapped
Orthologs:
Homo sapiens (human) : NNT (nicotinamide nucleotide transhydrogenase)  HGNC  Alliance
Mus musculus (house mouse) : Nnt (nicotinamide nucleotide transhydrogenase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nnt (nicotinamide nucleotide transhydrogenase)
Pan paniscus (bonobo/pygmy chimpanzee) : NNT (nicotinamide nucleotide transhydrogenase)
Canis lupus familiaris (dog) : NNT (nicotinamide nucleotide transhydrogenase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nnt (nicotinamide nucleotide transhydrogenase)
Sus scrofa (pig) : NNT (nicotinamide nucleotide transhydrogenase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0252,189,523 - 52,283,095 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0270,553,338 - 70,644,591 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4251,496,456 - 51,589,901 (-)NCBIRGSC3.4rn4RGSC3.4
Celera247,067,409 - 47,159,610 (-)NCBICelera
Cytogenetic Map2q15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Nnt
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1587346
Created: 2006-11-19
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.