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Gene: Cad (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase) Rattus norvegicus
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Symbol: Cad
Name: carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CRRD ID: 1588606
Description: Exhibits several functions, including aspartate carbamoyltransferase activity; carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; and dihydroorotase activity. Involved in several processes, including alpha-amino acid metabolic process; animal organ development; and pyrimidine-containing compound biosynthetic process. Localizes to several cellular components, including cytosol; neuronal cell body; and terminal bouton. Used to study hepatocellular carcinoma. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy 50. Orthologous to human CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; beta-ureidopropionase deficiency pathway; Canavan disease pathway; INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; 4-amino-2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: INFERRED
Also known as: Cad_mapped; Carbamyl phosphatate synthetase; carbamyl phosphatate synthetase 2; carbamyl phosphatate synthetase 2 (mapped)
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0626,657,507 - 26,680,459 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl626,657,780 - 26,680,284 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0636,472,498 - 36,495,450 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4625,272,416 - 25,296,266 (-)NCBIRGSC3.4rn4RGSC3.4
Celera624,783,039 - 24,805,943 (-)NCBICelera
Cytogenetic Map6q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Cad
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1588606
Created: 2006-11-19
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.