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Gene: Gla (galactosidase, alpha) Rattus norvegicus
Symbol: Gla
Name: galactosidase, alpha
Description: Exhibits alpha-galactosidase activity and galactoside binding activity. Predicted to be involved in several processes, including glycosylceramide catabolic process; negative regulation of nitric oxide biosynthetic process; and negative regulation of nitric-oxide synthase activity. Localizes to lysosome. Human ortholog(s) of this gene implicated in Fabry disease. Orthologous to human GLA (galactosidase alpha); PARTICIPATES IN Fabry disease pathway; galactose metabolic pathway; galactosemia pathway; INTERACTS WITH amphetamine; bisphenol A; dibutyl phthalate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: alpha-galactosidase A; galactosidase, alpha (mapped); Gla_mapped
Homo sapiens (human) : GLA (galactosidase alpha)  HGNC  Alliance
Mus musculus (house mouse) : Gla (galactosidase, alpha)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gla (galactosidase alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : GLA (galactosidase alpha)
Canis lupus familiaris (dog) : GLA (galactosidase alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gla (galactosidase alpha)
Sus scrofa (pig) : GLA (galactosidase alpha)
Chlorocebus sabaeus (African green monkey) : GLA (galactosidase alpha)
Heterocephalus glaber (naked mole-rat) : Gla (galactosidase alpha)
more info ...
Allele / Splice: Glaem2Mcwi  
Genetic Models: DA-Glaem2Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0X105,405,915 - 105,417,331 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX105,406,792 - 105,417,323 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X105,295,029 - 105,306,686 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X122,044,703 - 122,056,327 (-)NCBIRGSC3.4rn4RGSC3.4
CeleraX98,809,769 - 98,821,187 (-)NCBICelera
Cytogenetic MapXq32NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Gla
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1589721
Created: 2006-11-19
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.