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Gene: Tyr (tyrosinase) Rattus norvegicus
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Symbol: Tyr
Name: tyrosinase
Description: Predicted to have copper ion binding activity; monophenol monooxygenase activity; and protein dimerization activity. Involved in several processes, including pigmentation; response to cAMP; and response to vitamin D. Localizes to the cytosol and nucleus. Predicted to colocalize with the melanosome. Used to study oculocutaneous albinism. Human ortholog(s) of this gene implicated in melanoma (multiple); ocular albinism (multiple); oculocutaneous albinism (multiple); retinoschisis; and vitiligo. Orthologous to human TYR (tyrosinase); PARTICIPATES IN alkaptonuria pathway; disulfiram pharmacodynamics pathway; dopamine beta-hydroxylase deficiency pathway; INTERACTS WITH 6-propyl-2-thiouracil; actinomycin D; atrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: C; Tyr_mapped; tyrosinase (albino coat color) (mapped)
Orthologs:
Homo sapiens (human) : TYR (tyrosinase)  HGNC  Alliance
Mus musculus (house mouse) : Tyr (tyrosinase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tyr (tyrosinase)
Pan paniscus (bonobo/pygmy chimpanzee) : TYR (tyrosinase)
Canis lupus familiaris (dog) : TYR (tyrosinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tyr (tyrosinase)
Sus scrofa (pig) : TYR (tyrosinase)
more info ...
Allele / Splice: Tyrem1Kyo   TyrsiaKyo  
Genetic Models: KFRS2/Kyo DA-Tyrem1Kyo KFRS2/Kyo-/+
Is Marker For: Strains:   FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi   KFRS2/Kyo   KFRS2/Kyo-/+   DA-Tyrem1Kyo   F344-TyrCKitH/Kyo   F344-AsipATyrCKitH/Kyo  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01151,012,598 - 151,106,802 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01157,322,968 - 157,416,594 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41143,641,257 - 143,746,315 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1139,445,261 - 139,532,999 (-)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Tyr
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1589755
Created: 2006-11-19
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.