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Gene: Pappa2 (pappalysin 2) Rattus norvegicus
Symbol: Pappa2
Name: pappalysin 2
Description: Predicted to have metallopeptidase activity. Involved in response to salt stress. Localizes to the apical plasma membrane and cytosol. Orthologous to human PAPPA2 (pappalysin 2); INTERACTS WITH bisphenol A; aflatoxin B1 (ortholog); all-trans-retinoic acid (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOC680069; LOC680415; pappalysin-2; similar to pappalysin 2 isoform 1; similar to Pappalysin-2 precursor (Pregnancy-associated plasma protein-A2) (PAPP-A2) (Pregnancy-associated plasma protein-E1) (PAPP-E)
Homo sapiens (human) : PAPPA2 (pappalysin 2)  HGNC  Alliance
Mus musculus (house mouse) : Pappa2 (pappalysin 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pappa2 (pappalysin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : PAPPA2 (pappalysin 2)
Canis lupus familiaris (dog) : PAPPA2 (pappalysin 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pappa2 (pappalysin 2)
Sus scrofa (pig) : PAPPA2 (pappalysin 2)
more info ...
Allele / Splice: Pappa2em4Mcwi   Pappa2em5Mcwi  
Genetic Models: SS.BN-(D13Hmgc1048-D13Hmgc1050)-Pappa2em4Mcwi SS.BN-(D13Hmgc1048-D13Hmgc1050)-Pappa2em5Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01376,389,150 - 76,660,248 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01381,303,663 - 81,574,402 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41374,286,881 - 74,379,736 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1370,687,413 - 70,959,267 (-)NCBICelera
Cytogenetic Map13q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Pappa2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1591785
Created: 2006-11-20
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.