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Gene: Isx (intestine-specific homeobox) Rattus norvegicus
Symbol: Isx
Name: intestine-specific homeobox
CRRD ID: 1592776
Description: Predicted to have DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of intestinal absorption; regulation of transcription by RNA polymerase II; and regulation of vitamin A metabolic process. Predicted to localize to nucleus. Orthologous to human ISX (intestine specific homeobox); INTERACTS WITH bisphenol A; 1,2-dimethylhydrazine (ortholog); 2,3,7,8-tetrachlorodibenzodioxine (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOC682968; similar to Retinal homeobox protein Rx (DRx1) (DRx)
Homo sapiens (human) : ISX (intestine specific homeobox)  HGNC  Alliance
Mus musculus (house mouse) : Isx (intestine specific homeobox)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Isx (intestine specific homeobox)
Pan paniscus (bonobo/pygmy chimpanzee) : ISX (intestine specific homeobox)
Canis lupus familiaris (dog) : ISX (intestine specific homeobox)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Isx (intestine specific homeobox)
Sus scrofa (pig) : ISX (intestine specific homeobox)
Chlorocebus sabaeus (African green monkey) : ISX (intestine specific homeobox)
Heterocephalus glaber (naked mole-rat) : Isx (intestine specific homeobox)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01914,198,899 - 14,219,269 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1914,198,899 - 14,218,531 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01925,312,031 - 25,333,241 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1913,089,232 - 13,110,157 (+)NCBICelera
Cytogenetic Map19p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Isx
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1592776
Created: 2006-11-20
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.