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Gene: Eng (endoglin) Rattus norvegicus
Symbol: Eng
Name: endoglin
Description: Exhibits type II transforming growth factor beta receptor binding activity. Predicted to contribute to BMP binding activity and transforming growth factor beta binding activity. Involved in several processes, including cellular response to mechanical stimulus; positive regulation of collagen biosynthetic process; and positive regulation of macromolecule metabolic process. Localizes to cell surface and extracellular space. Used to study congestive heart failure; pre-eclampsia; and renal fibrosis. Biomarker of cholestasis; congestive heart failure; hepatocellular carcinoma; hypertension (multiple); and renal fibrosis. Human ortholog(s) of this gene implicated in arteriovenous malformation; arteriovenous malformations of the brain; breast cancer; hereditary hemorrhagic telangiectasia; and intracranial aneurysm. Orthologous to human ENG (endoglin); PARTICIPATES IN hypoxia inducible factor pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4-amino-2,6-dinitrotoluene; amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: MGC124909
Homo sapiens (human) : ENG (endoglin)  HGNC  Alliance
Mus musculus (house mouse) : Eng (endoglin)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Eng (endoglin)
Pan paniscus (bonobo/pygmy chimpanzee) : ENG (endoglin)
Canis lupus familiaris (dog) : ENG (endoglin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Eng (endoglin)
Sus scrofa (pig) : ENG (endoglin)
Chlorocebus sabaeus (African green monkey) : ENG (endoglin)
Heterocephalus glaber (naked mole-rat) : Eng (endoglin)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0311,679,530 - 11,717,486 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl311,679,530 - 11,717,485 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0317,021,673 - 17,058,548 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera310,675,660 - 10,713,537 (+)NCBICelera
Cytogenetic Map3p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Eng
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1593188
Created: 2006-11-20
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.