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Gene: Itga4 (integrin subunit alpha 4) Rattus norvegicus
Symbol: Itga4
Name: integrin subunit alpha 4
Description: Exhibits cell adhesion molecule binding activity; fibronectin binding activity; and protein antigen binding activity. Predicted to contribute to C-X3-C chemokine binding activity. Involved in several processes, including clathrin-dependent extracellular exosome endocytosis; neuron projection morphogenesis; and positive regulation of leukocyte migration. Localizes to several cellular components, including extracellular exosome; growth cone; and neuronal cell body. Used to study anti-basement membrane glomerulonephritis; diabetic retinopathy; nephritis; and pneumonia. Biomarker of pre-eclampsia. Human ortholog(s) of this gene implicated in autism spectrum disorder and pancreatic cancer. Orthologous to human ITGA4 (integrin subunit alpha 4); PARTICIPATES IN altered integrin mediated signaling pathway; integrin mediated signaling pathway; pancreatic cancer pathway; INTERACTS WITH (+)-pilocarpine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Also known as: integrin alpha 4; integrin alpha 4 (mapped); integrin alpha-4; integrin, alpha 4; Itga4_mapped
Homo sapiens (human) : ITGA4 (integrin subunit alpha 4)  HGNC  Alliance
Mus musculus (house mouse) : Itga4 (integrin alpha 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itga4 (integrin subunit alpha 4)
Pan paniscus (bonobo/pygmy chimpanzee) : ITGA4 (integrin subunit alpha 4)
Canis lupus familiaris (dog) : ITGA4 (integrin subunit alpha 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itga4 (integrin subunit alpha 4)
Sus scrofa (pig) : ITGA4 (integrin subunit alpha 4)
Chlorocebus sabaeus (African green monkey) : ITGA4 (integrin subunit alpha 4)
Heterocephalus glaber (naked mole-rat) : Itga4 (integrin subunit alpha 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0366,178,745 - 66,265,547 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl366,193,059 - 66,263,960 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0372,754,339 - 72,825,872 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4362,024,747 - 62,097,456 (+)NCBIRGSC3.4rn4RGSC3.4
Celera363,623,691 - 63,694,098 (+)NCBICelera
Cytogenetic Map3q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Itga4
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1593249
Created: 2006-11-20
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.