Gene: Itga4 (integrin subunit alpha 4) Rattus norvegicus
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Symbol: Itga4
Name: integrin subunit alpha 4
Description: Exhibits cell adhesion molecule binding activity, fibronectin binding activity, and protein antigen binding activity; predicted to contribute to C-X3-C chemokine binding activity; involved in several processes, including cell morphogenesis, cellular response to cytokine stimulus, and positive regulation of leukocyte migration; localizes to several cellular components, including the cell surface, extracellular exosome, and growth cone; used to study anti-basement membrane glomerulonephritis, diabetic retinopathy, nephritis, and pneumonia; biomarker of pre-eclampsia; orthologous to human ITGA4 (integrin subunit alpha 4); PARTICIPATES IN altered integrin mediated signaling pathway; integrin mediated signaling pathway; pancreatic cancer pathway; INTERACTS WITH (+)-pilocarpine; (RS)-amphetamine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: integrin alpha 4; integrin alpha 4 (mapped); integrin alpha-4; integrin, alpha 4; Itga4_mapped
Orthologs:
Homo sapiens (human) : ITGA4 (integrin subunit alpha 4)  HGNC  Alliance
Mus musculus (house mouse) : Itga4 (integrin alpha 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itga4 (integrin subunit alpha 4)
Pan paniscus (bonobo/pygmy chimpanzee) : ITGA4 (integrin subunit alpha 4)
Canis lupus familiaris (dog) : ITGA4 (integrin subunit alpha 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itga4 (integrin subunit alpha 4)
Sus scrofa (pig) : ITGA4 (integrin subunit alpha 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0366,178,745 - 66,265,547 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0372,754,339 - 72,825,872 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4362,024,747 - 62,097,456 (+)NCBIRGSC3.4rn4RGSC3.4
Celera363,623,691 - 63,694,098 (+)NCBICelera
Cytogenetic Map3q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Itga4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1593249
Created: 2006-11-20
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.