Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Tyrp1 (tyrosinase-related protein 1) Rattus norvegicus
Symbol: Tyrp1
Name: tyrosinase-related protein 1
Description: Predicted to have monophenol monooxygenase activity; protein heterodimerization activity; and protein homodimerization activity. Predicted to be involved in several processes, including acetoacetic acid metabolic process; melanosome organization; and positive regulation of melanin biosynthetic process. Predicted to localize to clathrin-coated endocytic vesicle membrane; endosome membrane; and melanosome membrane. Human ortholog(s) of this gene implicated in oculocutaneous albinism; oculocutaneous albinism type III; and pigmentation disease. Orthologous to human TYRP1 (tyrosinase related protein 1); PARTICIPATES IN tyrosine metabolic pathway; INTERACTS WITH bisphenol A; cocaine; decabromodiphenyl ether.
Type: protein-coding
Also known as: 5,6-dihydroxyindole-2-carboxylic acid oxidase; B; tyrosinase-related protein 1 (mapped); tyrosine phosphatase 1, same as B (Brown); Tyrp1_mapped
Homo sapiens (human) : TYRP1 (tyrosinase related protein 1)  HGNC  Alliance
Mus musculus (house mouse) : Tyrp1 (tyrosinase-related protein 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tyrp1 (tyrosinase related protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TYRP1 (tyrosinase related protein 1)
Canis lupus familiaris (dog) : TYRP1 (tyrosinase related protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tyrp1 (tyrosinase related protein 1)
Sus scrofa (pig) : TYRP1 (tyrosinase related protein 1)
Chlorocebus sabaeus (African green monkey) : TYRP1 (tyrosinase related protein 1)
Heterocephalus glaber (naked mole-rat) : Tyrp1 (tyrosinase related protein 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0598,387,291 - 98,406,083 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl598,387,291 - 98,406,083 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05102,430,674 - 102,449,645 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4599,518,306 - 99,537,289 (+)NCBIRGSC3.4rn4RGSC3.4
Celera593,854,189 - 93,872,732 (+)NCBICelera
Cytogenetic Map5q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Tyrp1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1593266
Created: 2006-11-20
Species: Rattus norvegicus
Last Modified: 2020-03-31
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.