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Gene: RT1-Da (RT1 class II, locus Da) Rattus norvegicus
Symbol: RT1-Da
Name: RT1 class II, locus Da
Description: Predicted to have peptide antigen binding activity and polysaccharide binding activity. Predicted to be involved in cognition and peptide antigen assembly with MHC class II protein complex. Predicted to localize to MHC class II protein complex; bounding membrane of organelle; and cell surface. Biomarker of prediabetes syndrome. Human ortholog(s) of this gene implicated in Parkinson's disease (multiple); allergic hypersensitivity disease; asthma; and autoimmune hypersensitivity disease (multiple). Orthologous to human HLA-DRA (major histocompatibility complex, class II, DR alpha); PARTICIPATES IN interleukin-12 signaling pathway; allograft rejection pathway; antigen processing and presentation pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DA1; H2-Ea; histocompatibility 2, class II antigen E alpha; MGC112637; MHC class II antigen RT1.D alpha chain; MHC class II RT1D alpha chain antigen; MHC RT1.u-D-alpha chain; RT1 class II, locus Da (mapped); RT1-D alpha; RT1-Da_mapped; RT1-Daa; RT1-Dab; RT1-Dac; RT1-Dad; RT1-Daf; RT1-Dah; RT1-Dak; RT1-Dal; RT1-Dam; RT1-Dan; RT1-Du alpha; RT1-u
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0204,127,644 - 4,132,616 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,127,644 - 4,132,616 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,207,782 - 6,212,754 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,636,310 - 4,641,282 (+)NCBIRGSC3.4rn4RGSC3.4
Celera206,115,646 - 6,120,618 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on RT1-Da
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1593283
Created: 2006-11-20
Species: Rattus norvegicus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.