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Gene: Hspa1a (heat shock protein family A (Hsp70) member 1A) Rattus norvegicus
Symbol: Hspa1a
Name: heat shock protein family A (Hsp70) member 1A
Description: Predicted to have several functions, including ATP binding activity; enzyme binding activity; and protein domain specific binding activity. Involved in several processes, including generation of neurons; response to ethanol; and response to ischemia. Localizes to membrane raft. Predicted to colocalize with COP9 signalosome. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; cystic fibrosis; rheumatic disease (multiple); schizophrenia (multiple); and toxic shock syndrome. Orthologous to several human genes including HSPA1B (heat shock protein family A (Hsp70) member 1B); PARTICIPATES IN antigen processing and presentation pathway; endocytosis pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (R)-lipoic acid; 1,3,5-trinitro-1,3,5-triazinane; 1-naphthyl isothiocyanate.
Type: protein-coding
Also known as: heat shock 70 kDa protein 1A; Heat shock 70 kDa protein 2; heat shock 70kD protein 1A; heat shock 70kD protein 1B; heat shock 70kD protein 1B (mapped); heat shock protein 1A; Heat shock protein 70-2; heat shock protein family A member 1A; Hsp70-1; Hsp70-2; HSP70.2; Hsp72; Hspa1; Hspa1b; Hspa2
Homo sapiens (human) : HSPA1A (heat shock protein family A (Hsp70) member 1A)  HGNC  Alliance
Mus musculus (house mouse) : Hspa1a (heat shock protein 1A)  MGI  Alliance
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hspa1a (heat shock protein family A (Hsp70) member 1A)
Chlorocebus sabaeus (African green monkey) : HSPA1A (heat shock protein family A (Hsp70) member 1A)
more info ...
Is Marker For: Strains:   SHR-Hspa1em1Mcwi  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: not annotated on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0204,875,834 - 4,881,751 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,877,324 - 4,879,779 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,956,234 - 6,962,151 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,945,716 - 3,959,552 (+)NCBIRGSC3.4rn4RGSC3.4
Celera204,152,570 - 4,158,467 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Hspa1a
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1593284
Created: 2006-11-20
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.