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Gene: Nlrp1b (NLR family, pyrin domain containing 1B) Rattus norvegicus
Symbol: Nlrp1b
Name: NLR family, pyrin domain containing 1B
Description: Predicted to have cysteine-type endopeptidase activator activity involved in apoptotic process; protein domain specific binding activity; and protein homodimerization activity. Predicted to be involved in negative regulation of cell communication; regulation of cysteine-type endopeptidase activity; and regulation of gene expression. Predicted to localize to NLRP3 inflammasome complex and nucleoplasm. Orthologous to human CARD8 (caspase recruitment domain family member 8); PARTICIPATES IN NOD-like receptor signaling pathway; INTERACTS WITH aflatoxin B1 (ortholog); Aroclor 1254 (ortholog); asbestos (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOC691998; NACHT, LRR and PYD domains-containing protein 1b allele 3-like; similar to NACHT, leucine rich repeat and PYD containing 1
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01057,755,957 - 57,847,867 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01057,500,498 - 57,596,098 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41058,027,087 - 58,108,465 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1054,987,574 - 55,051,227 (-)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Nlrp1b
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1593294
Created: 2006-11-20
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.