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Gene: En1 (engrailed homeobox 1) Rattus norvegicus
Symbol: En1
Name: engrailed homeobox 1
Description: Predicted to have DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II proximal promoter sequence-specific DNA binding activity. Involved in response to cocaine. Localizes to the membrane and nucleus. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human EN1 (engrailed homeobox 1); INTERACTS WITH bisphenol A; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (ortholog); 2,3,7,8-tetrachlorodibenzodioxine (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Also known as: engrailed 1; homeobox protein engrailed-1; LOC685360; LOW QUALITY PROTEIN: homeobox protein engrailed-1; similar to Homeobox protein engrailed-1 (Mo-En-1)
Homo sapiens (human) : EN1 (engrailed homeobox 1)  HGNC  Alliance
Mus musculus (house mouse) : En1 (engrailed 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : En1 (engrailed homeobox 1)
Canis lupus familiaris (dog) : EN1 (engrailed homeobox 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : En1 (engrailed homeobox 1)
Sus scrofa (pig) : EN1 (engrailed homeobox 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01336,532,758 - 36,537,888 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01341,634,070 - 41,638,896 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1331,623,592 - 31,629,063 (+)NCBICelera
Cytogenetic Map13q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
More on En1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1595088
Created: 2006-11-20
Species: Rattus norvegicus
Last Modified: 2019-10-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.