Gene: Ezh2 (enhancer of zeste 2 polycomb repressive complex 2 subunit) Rattus norvegicus
Analyze
Symbol: Ezh2
Name: enhancer of zeste 2 polycomb repressive complex 2 subunit
Description: Exhibits chromatin binding activity and transcription regulatory region DNA binding activity; involved in several processes, including histone H3-K27 methylation, negative regulation of transcription by RNA polymerase II, and nervous system development; localizes to the cytoplasm and nucleus; biomarker of leiomyoma, nonalcoholic fatty liver disease, and pancreatic cancer; orthologous to human EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit); PARTICIPATES IN histone modification pathway; methionine cycle/metabolic pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 17beta-estradiol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: enhancer of zeste 2; enhancer of zeste homolog 2; enhancer of zeste homolog 2 (Drosophila); histone-lysine N-methyltransferase EZH2; LOC312299; MGC189404; similar to Enhancer of zeste homolog 2 (ENX-1)
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0477,284,404 - 77,347,011 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04141,955,864 - 142,018,471 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4475,709,959 - 75,773,279 (-)NCBIRGSC3.4rn4RGSC3.4
Celera471,429,142 - 71,492,047 (-)NCBICelera
Cytogenetic Map4q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Ezh2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1595860
Created: 2006-11-20
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.