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Gene: AFF4 (AF4/FMR2 family member 4) Homo sapiens
Symbol: AFF4
Name: AF4/FMR2 family member 4
Description: Predicted to have DNA-binding transcription factor activity and double-stranded DNA binding activity. Predicted to be involved in transcription elongation from RNA polymerase II promoter. Localizes to the fibrillar center and transcription elongation factor complex.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AF4/FMR2 family, member 4; AF5Q31; ALL1 fused gene from 5q31; ALL1-fused gene from chromosome 5q31 protein; CHOPS; major CDK9 elongation factor-associated protein; MCEF; MGC75036
Mus musculus (house mouse) : Aff4 (AF4/FMR2 family, member 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Aff4 (AF4/FMR2 family, member 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aff4 (AF4/FMR2 family member 4)
Pan paniscus (bonobo/pygmy chimpanzee) : AFF4 (AF4/FMR2 family member 4)
Canis lupus familiaris (dog) : AFF4 (AF4/FMR2 family member 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aff4 (AF4/FMR2 family member 4)
Sus scrofa (pig) : AFF4 (AF4/FMR2 family member 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh385132,875,381 - 132,963,655 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375132,211,071 - 132,299,354 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365132,238,970 - 132,327,253 (-)NCBINCBI36hg18NCBI36
Celera5128,341,097 - 128,429,374 (-)NCBI
Cytogenetic Map5q31.1NCBI
HuRef5127,403,706 - 127,491,391 (-)NCBIHuRef
CHM1_15131,644,358 - 131,732,653 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on AFF4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1601873
Created: 2007-04-27
Species: Homo sapiens
Last Modified: 2019-10-29
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.